TOPAS-microdosimetry is an extension to the TOPAS toolkit that provides settings for common microdosimeters, scoring of lineal energy (y/dy) and a biological weight function based on microdosimetric properties.

The extension can be downloaded from here.

The extension is described in:
Zhu, H., Chen, Y., Sung, W., McNamara, A. L., Tran, L. T., Burigo, L. N., et al. (2019). The microdosimetric extension in TOPAS: development and comparison with published data. Physics in Medicine and Biology, 64(14), 145004.

TOPAS is a user-friendly simulation software layered upon the general-purpose Geant4 particle transport toolkit. It was designed specifically for medical physics applications by MGH, Stanford and UCSF.

Plastimatch is an open source software for image computation. Our main focus is high-performance volumetric registration of medical images, such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET).

Software for proton beam calculations.

An analytical approximation of the Bragg curve for therapeutic proton beams, by Thomas Bortfeld.

Documentation and source code (available in Fortran, MATLAB and Python):

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TOPAS-RBE is an extension to the TOPAS toolkit that provides the ability to score relative biological effectiveness (RBE) of proton therapy. We provide scorers for several different RBE models from the scientific literature, to enable easy comparison of results.

The extension can be downloaded from here and documentation can be found here.

TOPAS-nBio is an extension to the TOPAS toolkit that is being developed as part of an ongoing NCI-R01. The goal is to follow the approach of the TOPAS software package, making Monte Carlo simulations easy-to-use with focus on radiation biology at sub-cellular scales.