Harald Paganetti, PhD

Director of Physics Research
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Address: Massachusetts General Hospital
Department of Radiation Oncology
100 Blossom Street
Boston, MA 02114
Phone: 617 726 5847


Short Curriculum Vitae


Director of Physics Research

Current Committee Memberships

Oversight Committee of the Harvard Medical Physics Residency Program

National Council on Radiation Protection and Measurements (NCRP)

Editorial Board: Physics in Medicine and Biology


Report of Scholarship


4 Books edited

20 Book chapters

228 Peer-reviewed articles (19 sole author, 25 first author, 87 senior author)

H-index: 58


“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN:  978-1-936366-43-9 2015

“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)

“Proton Therapy Physics” 2nd edition: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2018; ISBN 9781138626508

Most recent (2018-2019) publications in peer-reviewed journals

  1. Botas P; Grassberger C; Sharp G and Paganetti H: Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Physics in Medicine and Biology 2018 63; 035023
  2. Gentile MS; Yeap BY; Goebel C; Gaudet D; Gallotto S; Weyman E; Morgan M; MacDonald SM; Giantsoudi D; Adams J; Paganetti H; Tarbell NJ; Kooy H and Yock TI: Brainstem Injury in Pediatric Patients with Posterior Fossa Tumors Treated with Proton Beam Therapy and Associated Dosimetric Factors. International Journal of Radiation Oncology, Biology and Physics 2018 100; 719-729
  3. Haas-Kogan D; Indelicato D; Paganetti H; Esiashvili N; Mahajan A; Yock T; Flampouri S; MacDonald S; Fouladi M; Stephen S; Kalapurakal J; Terezakis S; Kooy H; Grosshans D; Makrigiorgos M; Mishra K; Young Poussaint T; Cohen K; Fitzgerald T; Gondi V; Liu A; Michalski J; Mirkovic D; Mohan R; Perkins S; Wong K; Bhadrasain V; Buchsbaum J and Larry K: National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. International Journal of Radiation Oncology, Biology and Physics 2018 101; 152-168
  4. Unkelbach J and Paganetti H: Robust Proton Treatment Planning: Physical and Biological Optimization. Seminars in Radiation Oncology 2018 28; 88–96
  5. Ramos-Mendez JA; Perl J; Schuemann J; McNamara AL; Paganetti H and Faddegon BA: Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Physics in Medicine and Biology 2018 63; 105014
  6. Giantsoudi D; Adams J; MacDonald S and Paganetti H: Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy? Acta Oncologica 2018 57; 1259-1264
  7. Paganetti H and Giantsoudi D: Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy. Seminars in Radiation Oncology 2018 28; 256-263
  8. Mohan R; Held KD; Story MD; Grosshans D; Capala J; Blakely EA; Boerma M; Bortfeld T; Chang P; Combs SE; Durante M; Formenti S; Fornace Jr AJ; Krishnan S; Limoli C; Paganetti H; Prise K; Stewart R; Tinganelli W; Timmerman R; Vikram B; Weil M and Willers H: Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology. International Journal of Radiation Oncology, Biology and Physics 2018 100; 816-831
  9. Underwood TSA; Grassberger C; Bass R; MacDonald SM; Meyersohn NM; Yeap BY; Jimenez RB and Paganetti H: Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1. International Journal of Radiation Oncology, Biology and Physics 2018 101; 809-819
  10. Jin Y; Giantsoudi D; Fu L; Verburg J; Gjesteby L; Wang G; Paganetti H and De Man B: Metal artifact reduction for radiation therapy: a simulation study. Proc. SPIE 10573, Medical Imaging 2018: Physics of Medical Imaging, 105730Q
  11. McNamara AL; Ramos-Mendez J; Perl J; Held K; Dominguez N; Moreno EB; Henthorn NT; Kirkby KJ; Meylan S; Villagrasa C; Incerti S; Faddegon B; Paganetti H and Schuemann J: Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Physics in Medicine and Biology 2018 63; 175018
  12. Chen Y; Grassberger C; Li J; Hong TS and Paganetti H: Impact of potentially variable RBE in liver proton therapy. Physics in Medicine and Biology 2018 63; 195001
  13. Paganetti H: Proton relative biological effectiveness - Uncertainties and opportunities. International Journal of Particle Therapy 2018 5; 2-14
  14. McMahon SJ; Paganetti H and Prise KM: LET-weighted doses effectively reduce biological variability in proton radiotherapy planning. Physics in Medicine and Biology 2018 63; 225009
  15. Tucker SL; Xu T; Paganetti H; Deist T; Verma V; Choi N; Mohan R; and Liao Z: Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk than Mean Lung Dose: Secondary Analysis of a Randomized Trial. International Journal of Radiation Oncology, Biology and Physics 2018 in press; online ahead of print
  16. Schuemann J; McNamara AL; Warmenhoven JW; Henthorn NT; Kirkby K; Merchant MJ; Ingram S; Paganetti H; Held KD; Ramos-Mendez J; Faddegon B; Perl J; Goodhead DT; Plante I; Rabus H; Nettelbeck H; Friedland W; Kundrát P; Ottolenghi A; Baiocco G; Barbieri S; Dingfelder M; Incerti S; Villagrasa C; Bueno M; Bernal MA; Guatelli S; Sakata D; Brown JMC; Francis Z; Kyriakou I; Lampe N; Ballarini F; Carante MP; Davídková M; Štěpán V; Jia X; Cucinotta FA; Schulte R; Stewart RD; Carlson DJ; Galer S; Kuncic Z; Lacombe S; Milligan J; Cho SH; Sawakuchi G; Inaniwa T; Sato T; Li W; Solov’yov AV; Surdutovich E; Durante M; Prise K and McMahon SJ: A new Standard DNA Damage (SDD) data format. Radiation Research 2018; online ahead of print
  17. Durante M; Paganetti H; Pompos A; Kry SF; Wu X and Grosshans DR: Report of a National Cancer Institute Special Panel: Characterization of the Physical Parameters of Particle Beams for Biological Research. Medical Physics 2018; online ahead of print
  18. Botas P; Kim J; Winey BA and Paganetti H: Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations. Physics in Medicine and Biology 2019 64; 015004
  19. Schuemann J; McNamara AL; Ramos-Méndez J; Perl J; Held KD; Paganetti H; Incerti S and Faddegon B: TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiation Research 2019; online ahead of print
  20. Paganetti H; Blakely E; Carabe-Fernandez A; Carlson DJ; Das IJ; Dong L; Grosshans D; Held KD; Mohan R; Moiseenko V; Niemierko A; Stewart RD and Willers H: Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Medical Physics 2019; online ahead of print
  21. Worstell WA; Adams BW; Aviles M; Bond J; Cascio E; Cremer T; El Fakhri G; Ertley CD; Foley MR; Grogg KS; Hamel CJ; Lu H-M; Lyashenko AV; Minot MJ; Paganetti H; Popecki MA; Stochaj ME: First results developing time-of-flight proton radiography for proton therapy applications. Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109480G


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