People Directory

Alejandro Bertolet, PhD

Head of B-Lab (Dosimetry and Modeling for RPT)
Assistant Professor of Radiation Oncology
headshot2023
E-mail:
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Address:Massachusetts General Hospital
Department of Radiation Oncology
100 Blossom Street
Boston, MA 02114
Phone:617-724-3665

Awards and Honors

  • 2023– 'One to Watch' in 2023, Society of Nuclear Medicine and Molecular Imaging
  • 2023 – Selected as Mentor for the Summer Fellowship Program by the American Association of Physicists in Medicine
  • 2023 – Early Career Investigator Travel Award by the Radiation Research Society
  • 2022 – Andrew L. Warshaw, M.D., Institute for Pancreatic Cancer Research Fellow
  • 2022 – Loeffler Team Science Seed Funding Program Recipient by the Department of Radiation Oncology at Mass General Hospital
  • 2022 – Extraordinary Ph.D. Award by the University of Sevilla
  • 2022 – Jack Fowler Award by the Radiation Research Society
  • 2021 – Selected for the Leadership Development Program for Researchers organized by the Mass General Hospital and Harvard Medical School
  • 2021 – Invited to the World Laureates Forum
  • 2019 – Best article of the month at the University of Sevilla
 

Publications

  • Bertolet A, Chamseddine I, Paganetti H, Schuemann J. The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. Frontiers in Oncology 2023, 13, p. 1196502. https://doi.org/10.3389/fonc.2023.1196502.
  • Suárez-García D, Cortés-Giraldo MA, Bertolet A. A systematic analysis of the particle irradiation data ensemble in the key of the microdosimetric kinetic model: Should clonogenic data be used for clinical relative biological effectiveness? Radiotherapy and Oncology, 2023, 185, p. 109730. https://doi.org/10.1016/j.radonc.2023.109730.
  • Zhang Q, Gerweck LE, Cascio EW, Gu L, Yang Q, Dong X, Huang P, Bertolet A, Nesteruk KP, Sung W, McNamara AL, Schuemann J. Absence of Tissue-Sparing Effects in Partial Proton FLASH Irradiation in Murine Intestine. Cancers 2023, 15(8), 2269, https://doi.org/10.3390/cancers15082269
  • Bobić M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H. Large anatomical changes in head-and-neck cancers – a dosimetric comparison of online and offline adaptive proton therapy. Clinical and Translational Radiation Oncology. 31 March 2023, 100625. https://doi.org/10.1016/j.ctro.2023.100625
  • Zhang Q, Gerweck LE, Cascio EW, Yang Q, Huang P, Niemierko A, Bertolet A, Nesteruk KP, McNamara AL, Schuemann J. Proton FLASH effects on mouse skin at different oxygen tensions. Phys Med Biol. 2023 Feb 2. PMID: 36731139, https://doi.org/10.1088/1361-6560/acb888
  • Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon S, Paganetti H, Schuemann J. Impact of DNA geometry and scoring on Monte Carlo track-structure simulations of initial radiation-induced damage. Radiation Research. 2022; 198(3):207-22. https://doi.org/10.1667/RADE-21-00179.1
  • Miras H, Terrón JA, Bertolet A, Leal A. Modified Geometry of 106Ru Asymmetric Eye Plaques to Improve Dosimetric Calculations in Ophthalmic Brachytherapy. J Pers Med. 2022 Apr 29;12(5). PMID: 35629144, PMCID: PMC9144752, https://doi.org/10.3390/jpm12050723
  • Bertolet A, Abolfath R, Carlson DJ, Lustig RA, Hill-Kayser C, Alonso-Basanta M, Carabe A. Correlation of LET With MRI Changes in Brain and Potential Implications for Normal Tissue Complication Probability for Patients With Meningioma Treated With Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):237-246. https://doi.org/10.1016/j.ijrobp.2021.08.027
  • Bertolet A, Wehrenberg-Klee E, Bobic M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol. 2021; 66 244002. https://doi.org/10.1088/1361-6560/ac43fd
  • Baratto-Roldán A, Bertolet A, Baiocco G, Carabe A, Cortés-Giraldo MA. Microdosimetry and dose-averaged LET calculations of protons in liquid water: a novel Geant4-DNA application. Frontiers in Physics. 2021 Oct 27 9:726787. https://doi.org/10.3389/fphy.2021.726787
  • Miras Del Río H, Ortiz Lora A, Bertolet Reina A, Terrón León JA. A Monte Carlo dose calculation system for ophthalmic brachytherapy based on a realistic eye model. Med Phys. 2021 Aug;48(8):4542-4559. PMID: 34250607, https://doi.org/10.1002/mp.15045
  • Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J. The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol. 2021 Jul 30;66(15). PMID: 34280910, PMCID: PMC8483580, https://doi.org/10.1088/1361-6560/ac15a5
  • Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. Implementation of the microdosimetric kinetic model using analytical microdosimetry in a treatment planning system for proton therapy. Phys Med. 2021 Jan;81:69-76. PMID: 33440283, https://doi.org/10.1016/j.ejmp.2020.11.024
  • Bertolet A, Wals A, Miras H, Macías J. Organic generation of real-world real-time data for clinical evidence in radiation oncology. Int J Med Inform. 2020 Dec;144:104301. PMID: 33091831, https://doi.org/10.1016/j.ijmedinf.2020.104301
  • Bertolet A, Grilj V, Guardiola C, Harken AD, Cortés-Giraldo MA, Baratto-Roldán A, Carabe A. Experimental validation of an analytical microdosimetric model based on Geant4-DNA simulations by using a silicon-based microdosimeter. Radiat Phys Chem Oxf Engl 1993. 2020 Nov;176. PMID: 33100611, PMCID: PMC7583143, https://doi.org/10.1016/j.radphyschem.2020.109060
  • Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. An Analytical Microdosimetric Model for Radioimmunotherapeutic Alpha Emitters. Radiat Res. 2020 Oct 2;194(4):403-410. PMID: 33045091, https://doi.org/10.1667/RADE-20-00045.1
  • Bertolet A, Carabe-Fernandez A. Clinical implications of variable relative biological effectiveness in proton therapy for prostate cancer. Acta Oncol. 2020 Oct;59(10):1171-1177. PMID: 32427011, https://doi.org/10.1080/0284186X.2020.1762928
  • Bertolet A, Carabe A. Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model. Life (Basel). 2020 Aug 23;10(9). PMID: 32842519, PMCID: PMC7555955, https://doi.org/10.3390/life10090161
  • Bertolet A, Carabe A. Proton monoenergetic arc therapy (PMAT) to enhance LETd within the target. Phys Med Biol. 2020 Aug 19;65(16):165006. PMID: 32428896, https://doi.org/10.1088/1361-6560/ab9455
  • Carabe A, Karagounis IV, Huynh K, Bertolet A, François N, Kim MM, Maity A, Abel E, Dale R. Radiobiological effectiveness difference of proton arc beams versus conventional proton and photon beams. Phys Med Biol. 2020 Aug 31;65(16):165002. PMID: 32413889, https://doi.org/10.1088/1361-6560/ab9370
  • Bertolet A, Cortés-Giraldo MA, Souris K, Carabe A. A kernel-based algorithm for the spectral fluence of clinical proton beams to calculate dose-averaged LET and other dosimetric quantities of interest. Med Phys. 2020 Jun;47(6):2495-2505. PMID: 32124463, https://doi.org/10.1002/mp.14108
  • Bertolet A, Cortés-Giraldo MA, Carabe-Fernandez A. On the concepts of dose-mean lineal energy, unrestricted and restricted dose-averaged LET in proton therapy. Phys Med Biol. 2020 Apr 2;65(7):075011. PMID: 32023557, https://doi.org/10.1088/1361-6560/ab730a
  • Carabe-Fernandez A, Bertolet-Reina A, Karagounis I, Huynh K, Dale RG. Is there a role for arcing techniques in proton therapy?. Br J Radiol. 2020 Mar 1;93(1107):20190469. PMID: 31860338, PMCID: PMC7066964, https://doi.org/10.1259/bjr.20190469
  • Bertolet A, Cortés-Giraldo MA, Souris K, Cohilis M, Carabe-Fernandez A. Calculation of clinical dose distributions in proton therapy from microdosimetry. Med Phys. 2019 Dec;46(12):5816-5823. PMID: 31603992, https://doi.org/10.1002/mp.13861
  • Bertolet A, Baratto-Roldán A, Cortés-Giraldo MA, Carabe-Fernandez A. Segment-averaged LET concept and analytical calculation from microdosimetric quantities in proton radiation therapy. Med Phys. 2019 Sep;46(9):4204-4214. PMID: 31228264, https://doi.org/10.1002/mp.13673
  • Bertolet A, Baratto-Roldán A, Barbieri S, Baiocco G, Carabe A, Cortés-Giraldo MA. Dose-averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations. Med Phys. 2019 Sep;46(9):4184-4192. PMID: 31169910, https://doi.org/10.1002/mp.13643
  • Miras H, Jiménez R, Perales Á, Terrón JA, Bertolet A, Ortiz A, Macías J. Monte Carlo verification of radiotherapy treatments with CloudMC. Radiat Oncol. 2018 Jun 27;13(1):99. PMID: 29945681, PMCID: PMC6020449, https://doi.org/10.1186/s13014-018-1051-9
 
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