Training

Medical Physics Resident

Harvard Medical School, Boston, MA

Expected completion: 06/2018

Education

University of Toronto, Toronto, Ontario, Canada

Doctor of Philosophy, Department of Medical Biophysics

Degree received: 06/2015

Thesis title: Porphyrin Microparticles for Biological and Biomedical Applications

McMaster University, Hamilton, Ontario, Canada

Bachelor of Science (Honors), Medical and Health Physics

Degree received: 06/2010

Honors and Awards

2013-2015 CIHR Frederick Banting and Charles Best Canada Graduate Scholarship ($30

000/ year + $5 000 research allowance/ year for 3 years; ranked 6 out of 852)

2012 Runner-up for best oral presentation, James Lepock Memorial Student Research

Symposium, Toronto, Canada

2012 Second prize for best poster, Biomedical Optics, Miami, USA, $300

2012 University of Toronto School of Graduate Studies Conference Grant, Toronto,

Canada, $440

2011 Best poster, World Molecular Imaging Congress, San Diego, USA, $100

2011 Best MSc poster, James Lepock Memorial Student Research Symposium,

Toronto, Canada, $100

2011 World Molecular Imaging Conference Travel Award, San Diego, USA, $350

2010-11 Dr. J.R. Cunningham Graduate Fellowship in Cancer Research, Toronto,

Canada, $10 000 per year

2009 Second prize for best poster, University of Toronto Medical Biophysics Summer

Student Research Day, Toronto, Canada

2006-10 Deans Honour List, McMaster University, Hamilton, Canada

2006-10 Queen Elizabeth II Aiming for the Top Scholarship, McMaster University,

Hamilton, Canada, $3500 per year

2006-10 McMaster University Entrance Scholarship, Hamilton, Canada, $2000 per year

Peer-reviewed Publications

1. Huynh E, Coroller TC, Narayan V, Agrawal V, Hou Y, Romano J, Franco I, Mak RH, Aerts

HJWL. CT-based radiomic analysis of stereotactic body radiation therapy patients with lung

cancer identifies non-invasive biomarkers for recurrent disease. Radiotherapy and

Oncology. 2016, submitted.

2. Shakiba M, Ng KK, Huynh E, Chan H, Charron DM, Muhanna N, Chen J, Foster SF, Irish

JC, Wilson BC, Zheng G. Stable J-aggregation enabled dual photoacoustic and

fluorescence nanoparticles for intraoperative cancer imaging. Nanoscale. 2016.

DOI:10.1039/C5NR08165C.

3. Yip SF, Coroller TC, Sanford N, Huynh E, Mamon H, Aerts HWJL, Berbeco R. Use of

registration-based contour propagation in texture analysis for esophageal cancer pathologic

response prediction. Physics in Medicine and Biology. 2016, 61(2), 906-22.

4. Paproski R, Forbrich A, Huynh E, Chen J, Lewis J, Zheng, G, Zemp R. Porphyrin

Nanodroplets: Submicron Ultrasound and Photoacoustic Contrast Imaging Agents. Small.

2015. DOI: 10.1002/smll.201502450.

5. Muhanna N, Cui L, Chan H, Burgess L, Jin CS, Huynh E, Wang, F, Chen J, Irish JC, Zheng

G. Multimodal Image-Guided Surgical and Photodynamic Interventions in Head-and-Neck

Cancer: From Primary Tumor to Metastatic Drainage. Clinical Cancer Research. 2015.

DOI: 10.1158/1078-0432.CCR-15-1235.

6. Muhanna N, Jin CS, Huynh E, Chan H, Qiu M, Jiang W, Cui L, Burgess L, Chen J, Irish JC,

Zheng G. Phototheranostic Porphyrin Nanoparticles Enable Visualization and Targeted

Treatment of Head and Neck Cancer in Large Animal Models. Theranostics. 2015, 5(12),

1428-1443.

7. Huynh E, Leung BYC, Helfield B, Shakiba M, Gandier J, Jin CS, Master E, Wilson BC,

Goertz, DE, Zheng G. In situ conversion of porphyrin microbubbles to nanoparticles for

multimodality imaging. Nature Nanotechnology. 2015, 10(4), 325-332.

 Featured in Nature Nanotechnology News and Views (2015, 10 (4), 301–302)

8. Ng KK, Shakiba M, Huynh E, Weersink R, Roxin A, Wilson BC, Zheng G. Reversible stimuliresponsive

photoacoustic nanoswitch for in vivo sensing applications. ACS Nano. 2014,

8(8), 8363-8373.

9. Huynh E, Jin CS, Wilson BC, Zheng G. Aggregate enhanced porphyrin shell microbubbles

for ultrasound, photoacoustic and fluorescence imaging. Bioconjugate Chemistry. 2014,

25(4), 796-801.

10. Huynh E, Zheng G. Porphysome nanotechnology: a paradigm shift in lipid-based

supramolecular structures. NanoToday. 2014, 9(2), 212-222. 

11. Jeon M, Song W, Huynh E, Kim J, Kim J, Helfield BL, Leung B, Goertz DE, Zheng G, Oh J,

Lovell JF, Kim C. Methylene blue microbubbles (MB2) as a model dual-modality contrast

agent for ultrasound and activatable photoacoustic imaging. Journal of Biomedical Optics.

2014, 19(1), 016005-1 – 016005-8.

12. Huynh E, Zheng G. Organic biophotonic nanoparticles: porphysomes and beyond. IEEE

Journal of Selected Topics in Quantum Electronics. 2014, 20(3). 1-8.

13. Huynh E, Lovell JF, Fobel R, Zheng G. Optically controlled pore formation in self-sealing

giant porphyrin vesicles. Small. 2014, 10(6), 1184-1193.

14. Huynh E, Zheng G. Engineering multifunctional nanoparticles: all-in-one versus one-for-all.

Wiley Interdisciplinary Reviews Nanomedicine and Nanotechnology. 2013, 5(3), 250-

265.

15. Huynh E, Lovell JF, Helfield B, Jeon M, Kim C, Goertz DE, Wilson BC, Zheng G. Porphyrin

shell microbubbles with intrinsic ultrasound and photoacoustic properties. Journal of the

American Chemical Society. 2012, 134(40), 16464-16467.

 Selected as cover feature for October 10, 2012 issue

 Featured in Journal of the American Chemical Society as a spotlight article (2012,

134, 16447−16448)

16. Lovell JF, Jin CS, Huynh E, MacDonald TD, Cao W, Zheng G. Enzymatic regioselection for

synthesis and biodegradation of porphysome nanovesicles. Angewandte Chemie

International Edition. 2012, 51(10), 2429-2433.

17. Lovell JF, Jin CS, Huynh E, Jin H, Kim C, Rubinstein JL, Chan WCW, Wang LV, Zheng G.

Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal

biophotonic contrast agents. Nature Materials. 2011, 10, 324-332.

18. Lovell JF, Chen J, Huynh E, Jarvi MT, Wilson BC, Zheng, G. Facile synthesis of advanced

photodynamic molecular beacon architectures. Bioconjugate Chemistry. 2010, 21, 1023-

1025.

Other Publications

Editorial

Huynh E and Zheng G. Cancer nanomedicine: addressing the dark side of the enhanced

permeability and retention effect. Nanomedicine. 2015, 10(13), 1993-5.

“In the Classroom” Article - An invited article by the editor of Nature Nanotechnology to

describe the journey, lessons and challenges of the study.

Huynh E. From nano to micro and back. Nature Nanotechnology. 2015, 10(4), 380. 

Book Chapter

Liu TW, Huynh E, MacDonald TD, Zheng G. Porphyrins for Imaging, Photodynamic Therapy

and Photothermal Therapy. Cancer Theranostics. Elsevier Inc., 2014. p229-248.

Research Highlights

Lovell JF, Huynh E, MacDonald TD, Lin Q, Zheng G. Research Highlight. Nanomedicine. 2011,

6(7), 1155-1158.

Patents

Provisional patents filed:

2013 J-aggregate Forming Nanoparticles (Zheng G, Ng KK, Huynh E, Shakiba M,

Weersink R, Wilson B) (filed on Jan 29, 2013)

US Prov. Appl. No. 61/757,750

2011 Controlled Opening of Self-Sealing Porphyrin Microvesicles (Zheng G, Huynh E,

Lovell JF) (filed on Oct 25, 2011)

US Patent Application No. US61/568,352

PCT/CA2012/001122

2011 Porphyrin Shell Microbubble Contrast Agents (Zheng G, Huynh E, Lovell JF)

(filed on Oct 13, 2011)

WO 2013053042 A1

PCT/CA2012/000937

Selected Conference Presentations

1. Huynh E, Goertz DG, Zheng G. “Imaging the Microbubble to Nanoparticle Conversion using

Ultrasound, Photoacoustics and Fluorescence.” Poster presentation. Laser Applications in

Life Sciences. Ulm, Germany. June 29-July 2, 2014.

2. Huynh E, Zheng G. “Aggregate Enhanced Trimodal Porphyrin Shell Microbubbles for

Ultrasound, Photoacoustic and Fluorescence Imaging.” Poster presentation. SPIE Photonics

West. San Francisco, California. February 1-6, 2014.

3. Huynh E, Lovell JF, Zheng G. “Optically Controlled Pore Formation in Cell-Size Porphyrin

Vesicles.” Poster presentation. Biophotonics School. Island of Ven, Sweden. June 8-15,

2013.

4. Huynh E, Lovell JF, Kim C, Goertz DE, Wilson BC, Zheng G. “Photonic Porphyrin Shell

Microbubbles as a Dual Modal Ultrasound and Photoacoustic Contrast Agent.” Oral

Presentation. Seventh International Conference on Porphyrins and Phthalocyanines. July 4,

2012. 

5. Huynh E, Lovell JF, Zheng G. “Optically Controlled Opening of Photonic Cell-Size PorphyrinLipid

Vesicles as Versatile Microreactors.” Oral Presentation. James Lepock Memorial

Student Symposium, University of Toronto, Toronto, Canada. June 14, 2012. Runner-up for

Best MSc Oral Presentation.

6. Huynh E, Lovell JF, Zheng G. “Optically Controlled Opening of Self-Sealing Giant Porphyrin

Vesicles.” Poster Presentation. Biomedical Optics Optical Society of America, Miami, United

States of America. April 29-May 2, 2012. Awarded Second Prize for Best Poster.

7. Huynh E, Lovell JF, Zheng G. “Structure Dependent Photoacoustic and Fluorescence

Properties of Porphysome Nanovesicles”. Poster Presentation. World Molecular Imaging

Congress, San Diego, United States of America. September 7-11, 2011. Awarded Best

Poster in Optical and Photoacoustic Probes Category.

8. Huynh E, Lovell JF, Zheng G. “Porphysome Giant Vesicles: Investigating Porphyrin-Lipid

Bilayer Membrane Behaviour.” Poster Presentation. James Lepock Memorial Student

Research Symposium, University of Toronto, Toronto, Canada. June 2, 2011. Awarded

Best MSc Poster.

9. Huynh E, Lovell JF, Zheng G. “Improving Selectivity of Photosensitizers.” University of

Toronto Medical Biophysics Summer Student Research Day, Toronto, Canada. August 12,

2009. Awarded Second Prize for Best Poster.