Harald Paganetti, PhD

Director of Physics Research
Professor
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E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Address: Massachusetts General Hospital
Department of Radiation Oncology
Francis H. Burr Proton Therapy Center
30 Fruit St
Boston, MA 02114
Phone: 617 726 5847

 

Short Curriculum Vitae

 

Director of Physics Research

Current Committee Memberships

Oversight Committee of the Harvard Medical Physics Residency Program

National Council on Radiation Protection and Measurements (NCRP)

ASTRO: Chair: Annual meeting Physics Track

ASTRO: Annual Meeting Scientific Committee

ASTRO: Science Steering Committee

ASTRO: Best of ASTRO meeting; Program committee

Editorial Board: Physics in Medicine and Biology

 

Report of Scholarship

Overview:

3 Books

16 Book chapters

205 Peer-reviewed articles (18 sole author, 23 first author, 80 senior author)

H-index: 52

Books

“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN:  978-1-936366-43-9 2015

“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)

 

Most recent (2026-2018) publications in peer-reviewed journals

  1. Verburg JM; Grassberger C; Dowdell S; Schuemann J; Seco J and Paganetti H: Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technology in Cancer Research and Treatment 2016 15; NP35-NP46
  2. Paganetti H and Zietman A: Why Is Proton Beam Therapy So Controversial? Journal of the American College of Radiology 2015 12; 1318-1319
  3. McMahon SJ; Paganetti H and Prise KM: Optimising element choice for nanoparticle radiosensitisers. Nanoscale 2016 8; 581-589
  4. Dowdell S; Grassberger C; Sharp G and Paganetti H: Fractionated Lung IMPT Treatments: Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technology in Cancer Research and Treatment 2016 15; 689-696
  5. Geng C; Moteabbed M; Xie Y; Schuemann J; Yock T and Paganetti H: Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning. Physics in Medicine and Biology 2016 61; 12-22
  6. Hall DC; Makarova A; Paganetti H and Gottschalk B: Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam. Physics in Medicine and Biology 2016 61; N1-N10
  7. Geng C; Moteabbed M; Seco J; Gao Y; Xu XG; Ramos-Méndez J; Faddegon B and Paganetti H: Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Physics in Medicine and Biology 2016 61; 683-695
  8. Underwood T and Paganetti H: Variable Proton Relative Biological Effectiveness: How Do We Move Forward? International Journal of Radiation Oncology, Biology and Physics 2016 96; 59-61
  9. Liu Q; Underwood TSA; Kung J; Wang M; Lu H-M; Paganetti H; Held KD; Hong TS; Efstathiou JA and Willers H: Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation. International Journal of Radiation Oncology, Biology and Physics 2016 96; 78-85
  10. Moteabbed M; Yock TI; Depauw N; Madden TM; Kooy HM and Paganetti H: Impact of spot size and beam-shaping devices on the treatment plan quality for pencil beam scanning proton therapy. International Journal of Radiation Oncology, Biology and Physics 2016 96; 190-198
  11. Giantsoudi D; Sethi RV; Yeap BY; Eaton BR; Ebb DH; Caruso PA; Rapalino O; Chen YLE; Adams J; Yock TI; Tarbell NJ; Paganetti H and MacDonald SM: Incidence of CNS Injury for a Cohort of 111 Patients Treated with Proton Therapy for Medulloblastoma; LET and RBE Associations for Areas of Injury. International Journal of Radiation Oncology, Biology and Physics 2016 96; 287-296
  12. Underwood T; Giantsoudi D; Moteabbed M; Zietman A; Efstathiou J; Paganetti H and Lu H-M: Can we advance proton therapy for prostate? Considering alternative beam angles and RBE variations when comparing against IMRT. International Journal of Radiation Oncology, Biology and Physics 2016 95; 454-464
  13. Yonekura Y; Tsujii H; Hopewell JW; López PO; Cosset JM; Paganetti H; Montelius A; Schardt D; Jones B and Nakamura T: ICRP Publication 127: Radiological Protection in Ion Beam Radiotherapy. Annals of the ICRP 45(1 Suppl); 138-47
  14. Paganetti H; Yu CX and Orton G: Photon radiotherapy has reached its limit in terms of catching

up dosimetrically with proton therapy. Medical Physics 2016 43; 4465

  1. McNamara AL; Kam WW-Y; Scales N; McMahon SJ; Bennett JW; Byrne HL; Schuemann J; Paganetti H; Banati R and Kuncic Z: Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol. Physics in Medicine and Biology 2016 61; 5993-6010
  2. Durante M and Paganetti H: Nuclear physics in particle therapy: a review. Nuclear physics in particle therapy: a review. Reports on Progress in Physics 2016 79; 096702
  3. McMahon SJ; Schuemann J; Paganetti H and Prise KM: Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage. Nature Scientific Reports 2016 6; 33290
  4. Unkelbach J; Botas P; Giantsoudi D; Gorissen B and Paganetti H: Reoptimization of intensity-modulated proton therapy plans based on linear energy transfer. International Journal of Radiation Oncology, Biology and Physics 2016 96; 1097-1106
  5. Qin N; Botas P; Giantsoudi D; Schümann J; Tian Z; Jiang SB; Paganetti H and Jia X: Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Physics in Medicine and Biology 2016 61; 7347-7362
  6. Grassberger C and Paganetti H: Methodologies in the modeling of combined chemo-radiation treatments. Physics in Medicine and Biology 2016 61; R344-R367
  7. McMahon SJ; McNamara AL; Schuemann J; Prise KM and Paganetti H: Mitochondria as a target for radiosensitisation by gold nanoparticles. Journal of Physics: Conference Series 777 (2016) 012008
  8. Gjesteby L; De Man B; Jin Y; Paganetti H; Verburg J; Giantsoudi D and Wang G: Metal Artifact Reduction in CT: Where Are We After Four Decades? IEEE Access 2016 4; 5826-5849
  9. Grassberger C; Scott JG and Paganetti H: Bio-mathematical Optimization of Radiation Therapy in the Era of Targeted Agents. International Journal of Radiation Oncology, Biology and Physics 2017 97; 13-17
  10. Geng C; Daartz J; Lam-Tin-Cheung K; Bussiere M; Shih H; Paganetti H and Schuemann J: Limitations of analytical dose calculations for small field proton radiosurgery. Physics in Medicine and Biology 2017 62; 246-257
  11. Giantsoudi D; Adams J; MacDonald S.M. and Paganetti H: Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for LET and Dose/Volume Parameters for the Brainstem and Organs at Risk. International Journal of Radiation Oncology, Biology and Physics 2017 97; 401-410
  12. McNamara A; Geng C; Turner R; Ramos Mendez J; Perl J; Held K; Faddegon B; Paganetti H and Schuemann J: Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Physica Medica (European Journal of Medical Physics) 2017; 33 207-216
  13. Underwood TSA; Voog JC; Moteabbed M; Tang S; Soffen E; Cahlon O; Lu H-M; Zietman AL; Efstathiou JA and Paganetti H: Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams. Acta Oncologica 2017 56; 575-581
  14. Giantsoudi D; De Man B; Verburg J; Trofimov A; Jin Y; Wang G; Gjesteby L and Paganetti H: Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction. Physics in Medicine and Biology 2017 62; R49-R80
  15. Hall DC; Trofimov AV; Winey BA; Liebsch NJ and Paganetti H: Predicting patient-specific dosimetric benefits of proton therapy for skull-base tumors using a geometric knowledge-based method. International Journal of Radiation Oncology, Biology and Physics 2017 97; 1087-1094
  16. Giantsoudi D; Seco J; Eaton BR; Simeone FJ; Kooy H; Yock TI; Tarbell NJ; DeLaney TF; Adams J; Paganetti H and MacDonald SM: Evaluating Intensity Modulated Proton Therapy relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in CSI in Growing Pediatric Patients. International Journal of Radiation Oncology, Biology and Physics 2017 98; 37-46
  17. Wei RL; Mattes MD; Yu J; Thrasher A; Shu H-K; Paganetti H; De Los Santos J; Koontz B; Abraham C and Balboni T: Attitudes of Radiation Oncologists Toward Palliative and Supportive Care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO). Practical Radiation Oncology 2017; 7 113-119
  18. Cho J; Grogg K; Min CH; Zhu X; Paganetti H and El Fakhri G: Feasibility for using 13N decay signals for PET-mediated proton range verification. Medical Physics 2017 44; 1734-1746
  19. Underwood T; Sung W; McFadden C; McMahon S; Hall D; McNamara A; Paganetti H; Sawakuchi G and Schuemann J: Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Physics in Medicine and Biology 2017 62; 3237-3249
  20. Grassberger C and Paganetti H: Varying relative biological effectiveness in proton therapy: knowledge gaps. Acta Oncologica 2017 56; 761-762
  21. Sorriaux J; Testa M; Paganetti H; Orban de Xivry J; Lee JA; Traneus E; Souris K; Vynckier S and Sterpin E: Experimental assessment of proton dose calculation accuracy in inhomogeneous media. Physica Medica 2017 38; 10-15
  22. Sung W; Ye S-J; McNamara AL; McMahon SJ; Hainfeld J; Shin J; Smilowitz HM; Paganetti H and Schuemann J: Dependence of Gold Nanoparticle Radiosensitization on Cell Geometry. Nanoscale 2017 9; 5843-5853
  23. Sorriaux J; Testa M; Paganetti H; Bertrand D; Orban de Xivry J; Lee JA; Palmans H; Vynckier S and Sterpin E: Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Medical Physics 2017 44; 4919-4927
  24. Ramos-Méndez J; Schuemann J; Incerti S; Paganetti H; Schulte R and Faddegon B: Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Physics in Medicine and Biology 2017 62; 5908-5925
  25. Kry SF; Bednarz B; Howell RM; Dauer L; Followill D; Klein E; Paganetti H; Wang B; Wuu C-S and Xu XG: AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Medical Physics 2017
  26. McMahon SJ; McNamara AL; Schuemann J; Paganetti H and Prise KM: A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Nature Scientific Reports 2017 7; 10790
  27. Manem VSK, Grassberger C, Paganetti H: Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers 2017 9; E119
  28. Tran LT; Chartier L; Bolst D; Pogossov A; Guatelli S; Petasecca M; Lerch MLF; Prokopovich DA; Reinhard MI; Clasie B; Depauw N; Kooy H; Flanz J; McNamara A; Paganetti H; Beltran C; Furutani K; Perevertaylo VL; Jackson M and Rosenfeld AB: Characterisation of proton pencil beam scanning and passive beam using a high spatial resolution solid state microdosimeter. Medical Physics 2017 44; 6085-6095
  29. Paganetti H: Relating the Proton Relative Biological Effectiveness to Tumor Control and Normal Tissue Complication Probabilities assuming Inter-patient variability in α/β. Acta Oncologica 2017 56; 1379-1386
  30. Toltz A; Hoesl M; Schuemann J; Seuntjens J; Lu HM and Paganetti H: Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification. Journal of Applied Clinical Medical Physics 2017 18; 200-205
  31. Geng C; Paganetti H and Grassberger C: Prediction of treatment response for combined chemo- and radiation therapy for non-small cell lung cancer patients using a bio-mathematical model. Nature Scientific Reports 2017 19; 13542
  32. Botas P; Grassberger C; Sharp G and Paganetti H: Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Physics in Medicine and Biology 2018 63; 035023
  33. Gentile MS; Yeap BY; Goebel C; Gaudet D; Gallotto S; Weyman E; Morgan M; MacDonald SM; Giantsoudi D; Adams J; Paganetti H; Tarbell NJ; Kooy H and Yock TI: Brainstem Injury in Pediatric Patients with Posterior Fossa Tumors Treated with Proton Beam Therapy and Associated Dosimetric Factors. International Journal of Radiation Oncology, Biology and Physics 2018 100; 719-729
  34. Haas-Kogan D; Indelicato D; Paganetti H; Esiashvili N; Mahajan A; Yock T; Flampouri S; MacDonald S; Fouladi M; Stephen S; Kalapurakal J; Terezakis S; Kooy H; Grosshans D; Makrigiorgos M; Mishra K; Young Poussaint T; Cohen K; Fitzgerald T; Gondi V; Liu A; Michalski J; Mirkovic D; Mohan R; Perkins S; Wong K; Bhadrasain V; Buchsbaum J and Larry K: National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. International Journal of Radiation Oncology, Biology and Physics 2018 101; 152-168
  35. Unkelbach J and Paganetti H: Robust Proton Treatment Planning: Physical and Biological Optimization. Seminars in Radiation Oncology 2018 28: 88–96
  36. Ramos-Mendez JA; Perl J; Schuemann J; McNamara AL; Paganetti H and Faddegon BA: Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Physics in Medicine and Biology 2018 63; 105014
  37. Giantsoudi D; Adams J; MacDonald S and Paganetti H: Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy? Acta Oncologica 2018; in press (online ahead of print)
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