Harald Paganetti, PhD

Director of Physics Research
Professor
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E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Address: Massachusetts General Hospital
Department of Radiation Oncology
Francis H. Burr Proton Therapy Center
30 Fruit St
Boston, MA 02114
Phone: 617 726 5847

 

Short Curriculum Vitae

 

Director of Physics Research

Current Committee Memberships

Oversight Committee of the Harvard Medical Physics Residency Program

National Council on Radiation Protection and Measurements (NCRP)

ASTRO: Chair: Annual meeting Physics Track

ASTRO: Annual Meeting Scientific Committee

ASTRO: Clinical, Translational and Basic Science Advisory Committee

ASTRO: Science Steering Committee

ASTRO: Best of ASTRO meeting; Program committee

Editorial Board: Physics in Medicine and Biology

 

Report of Scholarship

Overview:

3 Books

16 Book chapters

201 Peer-reviewed articles (18 sole author, 23 first author, 78 senior author)

H-index: 50

Books

“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN:  978-1-936366-43-9 2015

“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)

 

Most recent publications in peer-reviewed journals

201.     Paganetti H: Relating the Proton Relative Biological Effectiveness to Tumor Control and Normal Tissue Complication Probabilities assuming Inter-patient variability in α/β. Acta Oncologica 2017; in press; online ahead of print

 

200.     Tran LT; Chartier L; Bolst D; Pogossov A; Guatelli S; Petasecca M; Lerch MLF; Prokopovich DA; Reinhard MI; Clasie B; Depauw N; Kooy H; Flanz J; McNamara A; Paganetti H; Beltran C; Furutani K; Perevertaylo VL; Jackson M and Rosenfeld AB: Characterisation of proton pencil beam scanning and passive beam using a high spatial resolution solid state microdosimeter. Medical Physics 2017; in press; online ahead of print

 

199.     Manem VSK, Grassberger C, Paganetti H: Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers 2017 9; E119

 

198.     McMahon SJ; McNamara AL; Schuemann J; Paganetti H and Prise KM: A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Nature Scientific Reports 2017 7; 10790

 

197.     Kry SF; Bednarz B; Howell RM; Dauer L; Followill D; Klein E; Paganetti H; Wang B; Wuu C-S and Xu XG: AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Medical Physics 2017

 

196.     Ramos-Méndez J; Schuemann J; Incerti S; Paganetti H; Schulte R and Faddegon B: Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Physics in Medicine and Biology 2017 62; 5908-5925

 

195.     Sorriaux J; Testa M; Paganetti H; Bertrand D; Orban de Xivry J; Lee JA; Palmans H; Vynckier S and Sterpin E: Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Medical Physics 2017 44; 4919-4927

 

194.     Sung W; Ye S-J; McNamara AL; McMahon SJ; Hainfeld J; Shin J; Smilowitz HM; Paganetti H and Schuemann J: Dependence of Gold Nanoparticle Radiosensitization on Cell Geometry. Nanoscale 2017 9; 5843-5853

 

193.     Sorriaux J; Testa M; Paganetti H; Orban de Xivry J; Lee JA; Traneus E; Souris K; Vynckier S and Sterpin E: Experimental assessment of proton dose calculation accuracy in inhomogeneous media. Physica Medica 2017 38; 10-15

 

192.     Grassberger C and Paganetti H: Varying relative biological effectiveness in proton therapy: knowledge gaps. Acta Oncologica 2017 56; 761-762

 

191.     Underwood T; Sung W; McFadden C; McMahon S; Hall D; McNamara A; Paganetti H; Sawakuchi G and Schuemann J: Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Physics in Medicine and Biology 2017 62; 3237-3249

 

190.     Cho J; Grogg K; Min CH; Zhu X; Paganetti H and El Fakhri G: Feasibility for using 13N decay signals for PET-mediated proton range verification. Medical Physics 2017 44; 1734-1746

 

189.     Wei RL; Mattes MD; Yu J; Thrasher A; Shu H-K; Paganetti H; De Los Santos J; Koontz B; Abraham C and Balboni T: Attitudes of Radiation Oncologists Toward Palliative and Supportive Care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO). Practical Radiation Oncology 2017; 7 113-119

 

188.     Giantsoudi D; Seco J; Eaton BR; Simeone FJ; Kooy H; Yock TI; Tarbell NJ; DeLaney TF; Adams J; Paganetti H and MacDonald SM: Evaluating Intensity Modulated Proton Therapy relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in CSI in Growing Pediatric Patients. International Journal of Radiation Oncology, Biology and Physics 2017 98; 37-46

 

187.     Hall DC; Trofimov AV; Winey BA; Liebsch NJ and Paganetti H: Predicting patient-specific dosimetric benefits of proton therapy for skull-base tumors using a geometric knowledge-based method. International Journal of Radiation Oncology, Biology and Physics 2017 97; 1087-1094

 

186.     Giantsoudi D; De Man B; Verburg J; Trofimov A; Jin Y; Wang G; Gjesteby L and Paganetti H: Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction. Physics in Medicine and Biology 2017 62; R49-R80

 

185.     Underwood TSA; Voog JC; Moteabbed M; Tang S; Soffen E; Cahlon O; Lu H-M; Zietman AL; Efstathiou JA and Paganetti H: Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams. Acta Oncologica 2017 56; 575-581

 

184.     McNamara A; Geng C; Turner R; Ramos Mendez J; Perl J; Held K; Faddegon B; Paganetti H and Schuemann J: Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Physica Medica (European Journal of Medical Physics) 2017; 33 207-216

 

183.     Giantsoudi D; Adams J; MacDonald S.M. and Paganetti H: Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for LET and Dose/Volume Parameters for the Brainstem and Organs at Risk. International Journal of Radiation Oncology, Biology and Physics 2017 97; 401-410

 

182.     Geng C; Daartz J; Lam-Tin-Cheung K; Bussiere M; Shih H; Paganetti H and Schuemann J: Limitations of analytical dose calculations for small field proton radiosurgery. Physics in Medicine and Biology 2017 62; 246-257

 

181.     Grassberger C; Scott JG and Paganetti H: Bio-mathematical Optimization of Radiation Therapy in the Era of Targeted Agents. International Journal of Radiation Oncology, Biology and Physics 2017 97; 13-17

 

180.     Gjesteby L; De Man B; Jin Y; Paganetti H; Verburg J; Giantsoudi D and Wang G: Metal Artifact Reduction in CT: Where Are We After Four Decades? IEEE Access 2016 4; 5826-5849

 

179.     McMahon SJ; McNamara AL; Schuemann J; Prise KM and Paganetti H: Mitochondria as a target for radiosensitisation by gold nanoparticles. Journal of Physics: Conference Series 777 (2016) 012008

 

178.     Grassberger C and Paganetti H: Methodologies in the modeling of combined chemo-radiation treatments. Physics in Medicine and Biology 2016 61; R344-R367

 

177.     Qin N; Botas P; Giantsoudi D; Schümann J; Tian Z; Jiang SB; Paganetti H and Jia X: Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Physics in Medicine and Biology 2016 61; 7347-7362

 

176.     Unkelbach J; Botas P; Giantsoudi D; Gorissen B and Paganetti H: Reoptimization of intensity-modulated proton therapy plans based on linear energy transfer. International Journal of Radiation Oncology, Biology and Physics 2016 96; 1097-1106

 

175.     McMahon SJ; Schuemann J; Paganetti H and Prise KM: Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage. Nature Scientific Reports 2016 6; 33290

 

174.     Durante M and Paganetti H: Nuclear physics in particle therapy: a review. Nuclear physics in particle therapy: a review. Reports on Progress in Physics 2016 79; 096702

 

173.     McNamara AL; Kam WW-Y; Scales N; McMahon SJ; Bennett JW; Byrne HL; Schuemann J; Paganetti H; Banati R and Kuncic Z: Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol. Physics in Medicine and Biology 2016 61; 5993-6010

 

172.     Paganetti H; Yu CX and Orton G: Photon radiotherapy has reached its limit in terms of catching up dosimetrically with proton therapy. Medical Physics 2016 43; 4465

 

171.     Yonekura Y; Tsujii H; Hopewell JW; López PO; Cosset JM; Paganetti H; Montelius A; Schardt D; Jones B and Nakamura T: ICRP Publication 127: Radiological Protection in Ion Beam Radiotherapy. Annals of the ICRP 45(1 Suppl); 138-47

 

170.     Underwood T; Giantsoudi D; Moteabbed M; Zietman A; Efstathiou J; Paganetti H and Lu H-M: Can we advance proton therapy for prostate? Considering alternative beam angles and RBE variations when comparing against IMRT. International Journal of Radiation Oncology, Biology and Physics 2016 95; 454-464

 

169.     Giantsoudi D; Sethi RV; Yeap BY; Eaton BR; Ebb DH; Caruso PA; Rapalino O; Chen YLE; Adams J; Yock TI; Tarbell NJ; Paganetti H and MacDonald SM: Incidence of CNS Injury for a Cohort of 111 Patients Treated with Proton Therapy for Medulloblastoma; LET and RBE Associations for Areas of Injury. International Journal of Radiation Oncology, Biology and Physics 2016 96; 287-296

 

168.     Moteabbed M; Yock TI; Depauw N; Madden TM; Kooy HM and Paganetti H: Impact of spot size and beam-shaping devices on the treatment plan quality for pencil beam scanning proton therapy. International Journal of Radiation Oncology, Biology and Physics 2016 96; 190-198

 

167.     Liu Q; Underwood TSA; Kung J; Wang M; Lu H-M; Paganetti H; Held KD; Hong TS; Efstathiou JA and Willers H: Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation. International Journal of Radiation Oncology, Biology and Physics 2016 96; 78-85

 

166.     Underwood T and Paganetti H: Variable Proton Relative Biological Effectiveness: How Do We Move Forward? International Journal of Radiation Oncology, Biology and Physics 2016 96; 59-61

 

165.     Geng C; Moteabbed M; Seco J; Gao Y; Xu XG; Ramos-Méndez J; Faddegon B and Paganetti H: Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Physics in Medicine and Biology 2016 61; 683-695

 

164.     Hall DC; Makarova A; Paganetti H and Gottschalk B: Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam. Physics in Medicine and Biology 2016 61; N1-N10

 

163.     Geng C; Moteabbed M; Xie Y; Schuemann J; Yock T and Paganetti H: Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning. Physics in Medicine and Biology 2016 61; 12-22

 

162.     Dowdell S; Grassberger C; Sharp G and Paganetti H: Fractionated Lung IMPT Treatments: Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technology in Cancer Research and Treatment 2016 15; 689-696

 

161.     McMahon SJ; Paganetti H and Prise KM: Optimising element choice for nanoparticle radiosensitisers. Nanoscale 2016 8; 581-589

 

160.     Paganetti H and Zietman A: Why Is Proton Beam Therapy So Controversial? Journal of the American College of Radiology 2015 12; 1318-1319

 

159.     Verburg JM; Grassberger C; Dowdell S; Schuemann J; Seco J and Paganetti H: Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technology in Cancer Research and Treatment 2016 15; NP35-NP46

 

158.     McNamara AL; Schuemann J and Paganetti H: A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data. Physics in Medicine and Biology 2015 60; 8399-8416

 

157.     Lin Y; Paganetti H; McMahon SJ and Schuemann J: Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons. Medical Physics 2015 42; 5890; named Editor’s choice

 

156.     Chetty IJ; Martel MK; Jaffray DA; Benedict SH; Hahn SM; Berbeco R; Deye J; Jeraj R; Kavanagh B; Krishnan S; Lee N; Low DA; Mankoff D; Marks LB; Ollendorf D; Paganetti H; Ross B; Siochi RAC; Timmerman RD and Wong JW: Technology for Innovation in Radiation Oncology. International Journal of Radiation Oncology, Biology and Physics 2015 93; 485-492

 

155.     Ramos-Mendez J; Perl J; Schuemann J; Shin J; Paganetti H and Faddegon B: A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy. Physics in Medicine and Biology 2015 60; 5037-5052

 

154.     Ramos-Mendez J; Perl J; Schuemann J; Shin J; Paganetti H and Faddegon B: Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Physics in Medicine and Biology 2015 60; 5019-5035

 

153.     Polster L; Schuemann J; Rinaldi I; Burigo L; McNamara A; Stewart R; Attili A; Carlson D; Sato T; Ramos-Mendez J; Faddegon B; Perl J and Paganetti H: Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Physics in Medicine and Biology 2015 60; 5053-5070

 

152.     Schuemann J; Giantsoudi D; Grassberger C; Moteabbed M; Min CH and Paganetti H: Assessing the clinical impact of approximations in analytical dose calculations for proton therapy. International Journal of Radiation Oncology, Biology and Physics 2015 92; 1157-1164

 

151.     Paganetti H and El Fakhri G: Monitoring Proton Therapy with PET. British Journal of Radiology 2015 88; 20150173

 

150.     Lin Y; McMahon S; Paganetti H and Schuemann J: Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy. Physics in Medicine and Biology 2015 60; 4149-4168

 

149.     Grassberger C; Dowdell S; Sharp GC and Paganetti H: Motion Mitigation for Lung Cancer Patients treated with Active Scanning Proton Therapy. Medical Physics 2015 42: 2462-2469

 

148.     Grogg K; Alpert NM; Zhu X; Min C-H; Testa M; Winey B; Normandin M; Shih HA; Paganetti H; Bortfeld T and El Fakhri G: Quantitative mapping of radioactivity production rate during proton therapy. International Journal of Radiation Oncology, Biology and Physics 2015; 92: 453-459

 

147.     Liu Q; Ghosh P; Magpayo N; Testa M; Tang S; Biggs P; Paganetti H; Efstathiou JA; Lu HM; Held KD and Willers H: Lung Cancer Cell Line Screen Links Fanconi Anemia Pathway Defects to Increased Relative Biological Effectiveness of Proton Radiation. International Journal of Radiation Oncology, Biology and Physics 2015 91: 1081-1089

 

146.     Paganetti H: Relating proton treatments to photon treatments via the relative biological effectiveness (RBE) – Should we revise the current clinical practice? International Journal of Radiation Oncology, Biology and Physics 2015 91: 892-894

 

145.     Klein EE; Dong L; Paganetti H and Tanderup K: The Far-Reaching Subject Matter of Medical Physics in Radiation Oncology. International Journal of Radiation Oncology, Biology and Physics 2015 91: 697–700

 

144.     Giantsoudi D; Schuemann J; Jia X; Dowdell S; Jiang S and Paganetti H: Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy: clinical cases study. Physics in Medicine and Biology 2015 60: 2257-2270

 

143.     Wouters BG; Skarsgard LD; Gerweck LE; Carabe-Fernandez A; Wong M; Durand RE; Nielson D; Bussiere MR; Wagner M; Biggs P; Paganetti H and Suit HD: Radiobiological Intercomparison of the 160 MeV and 230 MeV Proton Therapy Beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital. Radiation Research 2015 183: 147-187

 

142.     Nguyen J; Moteabbed M and Paganetti H: Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses. Medical Physics 2015 42: 81-89; Editor’s Pick

 

141.     Grassberger C; Lomax A and Paganetti H: Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Physics in Medicine and Biology 2015 60: 633-645

 

140.     Min CH; Zhu X; Grogg K; El Fakhri G; Winey B and Paganetti H: A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technology in Cancer Research and Treatment 2015 14: 320-325

 

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