People Directory

Harald Paganetti, PhD

Director of Physics Research
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Massachusetts General Hospital
Department of Radiation Oncology
100 Blossom Street
Boston, MA 02114
617 726 5847


Director of Physics Research

Current Committee Memberships

Oversight Committee of the Harvard Medical Physics Residency Program

National Council on Radiation Protection and Measurements (NCRP)

International Commission on Radiological Units and Measurements (ICRU); Report Committee 37

ASTRO Research Grants Evaluation Sub- Committee

NRG – Oncology: Chair, RBE White Paper committee

PTCOG-NA: Board of Directors

PTCOG: Research Proposals Sub-Committee

Executive Editorial Board: Physics in Medicine and Biology

Report of Scholarship


4 Books edited

22 Book chapters

301 Peer-reviewed articles (22 sole author, 29 first author, 110 senior author)

H-index: 84


“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN:  978-1-936366-43-9 2015

“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)

“Proton Therapy Physics” 2nd edition: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2018; ISBN 9781138626508

Publications in peer-reviewed journals in 2023 and 2024

  1. McCullum L; Shin J; Xing S; Beekman C; Schuemann J; Hong T; Duda D; Mohan R; Lin S; Correa-Alfonso CM; Domal S; Withrow J; Bolch W; Paganetti H and Grassberger C: Predicting Severity of Radiation Induced Lymphopenia in Individual Patients for Varying Dose Rate and Fractionation Using Dynamic 4D Blood Flow Simulations. International Journal of Radiation Oncology, Biology and Physics 2023 116; 1226-1233
  2. Chamseddine I; Kim Y; De B; El Naqa I; Duda DG; Wolfgang JA; Pursley J; Wo JY; Hong TS; Paganetti H; Koay EJ and Grassberger C: Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton Versus Photon Therapy in Hepatocellular Carcinoma.. International Journal of Radiation Oncology, Biology and Physics 2023 116; 1234-1243
  3. Lee H; Cheon B-W; Feld JW; Grogg K; Perl J; Faddegon B; Min CH; Paganetti H and Schuemann J: TOPAS-imaging: An extension to the TOPAS simulation toolkit for medical imaging systems. Physics in Medicine and Biology 2023
  4. Kim Y; Chamseddine I; Cho Y; Mohan R; Shusharina N; Paganetti H; Lin S; Kim JS; Yoon HI; Cho S and Grassberger C: Neural network based ensemble model to predict radiation induced lymphopenia after concurrent chemo-radiotherapy for non-small cell lung cancer from multiple institutions. Neoplasia 2023
  5. Correa-Alfonso CM; Withrow JA; Domal SJ; President B; Dawson R; McCullum L; Beekman C; Grassberger C; Paganetti H and Bolch WE: Intra-brain vascular models within the ICRP mesh-type adult reference phantoms for applications to internal dosimetry. Physics in Medicine and Biology 2023
  6. Bobić M; Lalonde A; Nesteruk KP; Lee H; Gorissen BL; Bertolet A; Busse P; Chan AW; Winey BA; Sharp GC; Verburg JM; Lomax AJ and Paganetti H: Large anatomical changes in head-and-neck cancers - A dosimetric comparison of online and offline adaptive proton therapy. Clinical and Translational Radiation Oncology 2023
  7. Lalonde A; Bobic M; Sharp GC; Winey B; Paganetti H: Evaluating the effect of anatomical changes and online adaptation on normal tissue complication probability for head and neck intensity modulated proton therapy. Physics in Medicine and Biology 2023
  8. Berrington de González A; Gibson TM; Lee C; Albert PS; Griffin KT; Liu D; Mille MM; Shin J; Bajaj BVM; Flood TE; Gallotto SL; Paganetti H; Ahmed SK; Eaton BR; Indelicato DJ; Milgrom SA; Palmer JD; Baliga S; Poppe MM; Tsang DS; Wong K and Yock TI: The Pediatric Proton and Photon Therapy Comparison Cohort: study design for a multi-center retrospective cohort to investigate subsequent cancers after pediatric radiotherapy. Advances in Radiation Oncology 2023
  9. Bertolet A; Chamseddine I; Paganetti H and Schuemann J: The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. Frontiers in Oncology 2023
  10. Paganetti H: A review on lymphocyte radiosensitivity and its impact on radiotherapy. Frontiers in Oncology 2023
  11. Nenoff L; Sudhyadhom A; Lau J; Sharp G; Paganetti H and Pursley J: Comparing predicted toxicities between hypofractionated proton and photon radiotherapy: does daily adaptation matter for liver? Cancers 2023
  12. Beekman C; Withrow JD; Pathak SP; Correa Alfonso CM; Dawson RJ; Carrasco-Rojas N; Sforza AR; Colon CG; Bolch WE; Grassberger C and Paganetti H: A stochastic model of blood flow to calculate blood dose during radiotherapy. Physics in Medicine and Biology 2023
  13. Warmenhoven JW; Henthorn NT; Ingram SP; Merchant MJ; Kirkby KJ; Schuemann J; McNamara A; Paganetti H; Prise KM and McMahon SJ: Effects of differing underlying assumptions in in silico models on predictions of DNA damage and repair. Radiation Research 2023
  14. Huesa-Berral C; Withrow JD; Dawson RJ; Beekman C; Bolch WE; Paganetti H; Wehrenberg-Klee E and Bertolet A: MIDOS: A novel stochastic model toward a treatment planning system for Microsphere DOSimetry in liver tumors. European Journal of Nuclear Medicine and Molecular Imaging 2023
  15. Bobic M; Christensen JB; Lee H; Choulilitsa E; Czerska K; Togno M; Safai S; Yukihara EG; Winey BA; Lomax AJ; Paganetti H; Albertini F and Nesteruk KP: Optically stimulated luminescence dosimeters for accurate measurement of the point dose and dose-weighted LET in adaptive proton therapy workflow. Frontiers in Oncology 2024; in press
  16. Moteabbed M; Bobić M; Paganetti H and Efstathiou JA: The role of proton therapy for prostate cancer in the setting of hip prosthesis. Cancers 2024; in press
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