Harald Paganetti, PhD

Director of Physics Research
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Address: Massachusetts General Hospital
Department of Radiation Oncology
100 Blossom Street
Boston, MA 02114

Phone: 617 726 5847

Research Team website


Director of Physics Research

Current Committee Memberships

Oversight Committee of the Harvard Medical Physics Residency Program

National Council on Radiation Protection and Measurements (NCRP)

ASTRO Research Grants Evaluation Subcommittee

ASTRO Science Council

Editorial Board: Physics in Medicine and Biology

Scientific Advisory Board The Cancer Terminator Foundation

Report of Scholarship


4 Books edited

22 Book chapters

263 Peer-reviewed articles (20 sole author, 28 first author, 101 senior author)

H-index: 72


“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN:  978-1-936366-43-9 2015

“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)

“Proton Therapy Physics” 2nd edition: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2018; ISBN 9781138626508

Most recent (2019-2021) publications in peer-reviewed journals

  1. Tucker SL; Xu T; Paganetti H; Deist T; Verma V; Choi N; Mohan R; and Liao Z: Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk than Mean Lung Dose: Secondary Analysis of a Randomized Trial. International Journal of Radiation Oncology, Biology and Physics 2019 103; 403-410
  2. Schuemann J; McNamara AL; Warmenhoven JW; Henthorn NT; Kirkby K; Merchant MJ; Ingram S; Paganetti H; Held KD; Ramos-Mendez J; Faddegon B; Perl J; Goodhead DT; Plante I; Rabus H; Nettelbeck H; Friedland W; Kundrát P; Ottolenghi A; Baiocco G; Barbieri S; Dingfelder M; Incerti S; Villagrasa C; Bueno M; Bernal MA; Guatelli S; Sakata D; Brown JMC; Francis Z; Kyriakou I; Lampe N; Ballarini F; Carante MP; Davídková M; Štěpán V; Jia X; Cucinotta FA; Schulte R; Stewart RD; Carlson DJ; Galer S; Kuncic Z; Lacombe S; Milligan J; Cho SH; Sawakuchi G; Inaniwa T; Sato T; Li W; Solov’yov AV; Surdutovich E; Durante M; Prise K and McMahon SJ: A new Standard DNA Damage (SDD) data format. Radiation Research 2019 191; 76-92
  3. Durante M; Paganetti H; Pompos A; Kry SF; Wu X and Grosshans DR: Report of a National Cancer Institute Special Panel: Characterization of the Physical Parameters of Particle Beams for Biological Research. Medical Physics 2019 46; e37-e52
  4. Schuemann J; McNamara AL; Ramos-Méndez J; Perl J; Held KD; Paganetti H; Incerti S and Faddegon B: TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiation Research 2019 191; 125-138
  5. Paganetti H; Blakely E; Carabe-Fernandez A; Carlson DJ; Das IJ; Dong L; Grosshans D; Held KD; Mohan R; Moiseenko V; Niemierko A; Stewart RD and Willers H: Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Medical Physics 2019 46; e53-e78
  6. Worstell WA; Adams BW; Aviles M; Bond J; Cascio E; Cremer T; El Fakhri G; Ertley CD; Foley MR; Grogg KS; Hamel CJ; Lu H-M; Lyashenko AV; Minot MJ; Paganetti H; Popecki MA and Stochaj ME: First results developing time-of-flight proton radiography for proton therapy applications. Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109480G
  7. Li Y; Dykstra M; Best TD; Pursley J; Chopra N; Keane FK; Khandeka MJ; Sharp GC; Paganetti H; Willers H; Fintelmann FJ and Grassberger C: Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiotherapy and Oncology 2019 136; 169-175
  8. Oesten H; von Neubeck C; Jakob A; Enghardt W; Krause M; McMahon SJ; Grassberger C; Paganetti H and Lühr A.: Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics. Radiation Research 2019; 191 532-544
  9. Newpower M; Schuemann J; Mohan R; Paganetti H and Titt U: Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research. International Journal of Particle Therapy 2019; 6 18-27
  10. Marteinsdottir M and Paganetti H: Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer. Physics in Medicine and Biology: 2019; 64 115027
  11. Zhu H; Chen Y; Sung W; McNamara AL; Tran LT; Burigo LN; Rosenfeld AB; Li J; Faddegon B; Schuemann J and Paganetti H: The microdosimetric extension in TOPAS: Development and comparison with published data. Physics in Medicine and Biology: 2019; 64 145004
  12. Grassberger C; Geng C; McClatchy III D; Kamran SC; Fintelmann F; Maruvka YE; Piotrowska Z; Willers H; Sequist LV; Hata A and Paganetti H: Determining Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies based on Patient-Specific Tumor Growth Trajectories. Cancer Research 2019; 79 3776-3788
  13. Meschini G; Seregni M; Molinelli S; Vai A; Phillips J; Sharp GC; Pella A; Valvo F; Ciocca M; Riboldi M; Paganetti H and Baroni G: Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams. Medical Physics 2019; 46 3663-3673
  14. Abhyankar YS; Dev S; Sarun OS; Saxena A; Joshi R; Darbari H; Sajish C; Sonavane UB; Gavane V; Deshpande A; Dixit T; Harsh R; Badwe R; Rath GK; Laskar S; Faddegon B; Perl J; Paganetti H; Schuemann J; Srivastava A; Obcemea C; Nath AK; Sharma A and Buchsbaum J: Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. European Journal of Medical Physics 2019; 64 166-173
  15. Gjesteby L; Shan H; Yang Q; Xi Y; Jin Y; Giantsoudi D; Paganetti H; De Man B and Wang G: A dual-stream deep convolutional network for reducing metal streak artifacts in CT images. Physics in Medicine and Biology 2019; 64 235003
  16. Marteinsdottir M; Schuemann J and Paganetti H: Impact of uncertainties in range and RBE on small field proton therapy. Physics in Medicine and Biology 2019; 64 205005
  17. Bekelman JE; Lu H; Pugh S; Baker K; Berg CD; de Gonzalez AB; Braunstein LZ; Bosch W; Chauhan C; Ellenberg S; Fang LC; Freedman GM; Hahn EA; Haffty BG; Khan AJ; Jimenez RB; Kesslering C; Ky B; Lee C; Lu HM; Mishra MV; Mullins CD; Mutter RW; Nagda S; Pankuch M; Powell SN; Prior FW; Schupak K; Taghian AG; Wilkinson JB; MacDonald SM; Cahlon O and the RadComp (Radiotherapy Comparative Effectiveness Consortium). BMJ Open 2019; 9:e025556
  18. McNamara A; Willers H and Paganetti H: Modelling variable proton relative biological effectiveness for treatment planning. British Journal of Radiology 2020; 93:2019033
  19. Niyazi M; Niemierko A; Paganetti H; Söhn M; Schapira E; Goldberg S; Adams J; Kim V; Oh KS; Hwang WL; Lu H-L; Belka C; Busse PM; Loeffler JS and Shih HA: Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiotherapy and Oncology 2020; 142:154-161
  20. Hammi A; Paganetti H and Grassberger C: Four-dimensional Blood Flow Model for Dose Calculation to Circulating Blood and Lymphocytes. Physics in Medicine and Biology 2020; 65 055008
  21. Zhu H; McNamara AL; Ramos-Mendez J; McMahon SJ; Henthorn NT; Faddegon B; Held KD; Perl J; Li J; Paganetti H and Schuemann J: A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio. Physics in Medicine and Biology 2020; 65:085015
  22. Meschini G; Kamp F; Hofmaier J; Reiner M; Sharp G; Paganetti H; Belka C; Wilkens JJ; Carlson DJ; Parodi K; Baroni G and Riboldi M: Modeling RBE-weighted dose variations in irregularly moving targets treated with carbon ion beams. Medical Physics 2020; 47:2768-2778
  23. McNamara AL; Hall DC; Shusharina N; Liu A; Wei X; Ajdari A; Mohan R; Liao Z and Paganetti H: Perspectives on the model-based approach to proton therapy trials: a retrospective study of a lung cancer randomized trial. Radiotherapy and Oncology 2020; 147:8-14
  24. Wang C-C; McNamara AL; Shin J; Schuemann J; Grassberger C; Taghian AG; Jimenez RB; MacDonald SM and Paganetti H: End-of-range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. International Journal of Radiation Oncology, Biology and Physics 2020; 107:449-454
  25. Faddegon B; Ramos-Mendez J; Schuemann J; McNamara A; Shin J; Perl J and Paganetti H: The TOPAS Tool for Particle Simulation, a Monte Carlo Simulation Tool for Physics, Biology and Clinical Research. European Journal of Medical Physics / Physica Medica 2020; 72:114-121
  26. Zhu H; McNamara AL; McMahon SJ; Ramos-Mendez J; Henthorn NT; Faddegon B; Held KD; Perl J; Li J; Paganetti H and Schuemann J: Cellular response to proton irradiation: a simulation study with TOPAS-nBio. Radiation Research 2020; 194:9-21
  27. Shan H; Jia X; Yan P; Li Y; Paganetti H and Wang G: Synergizing Medical Imaging and Radiotherapy with Deep Learning. Machine Learning: Science and Technology 2020
  28. Delaney TF; Yock T and Paganetti H: Assessing Second Cancer Risk after Primary Cancer Treatment with Photon or Proton Radiotherapy: Cancer 2020 126; 3397-3399
  29. Shin J; Kooy HM; Paganetti H and Clasie B: DICOM-RT Ion interface to utilize MC simulations in routine clinical workflow for proton pencil beam radiotherapy: European Journal of Medical Physics / Physica Medica 2020 74; 1-10
  30. Paganetti H; Depauw N; Johnson A; Forman RB; Lau J and Jimenez R: The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques: Radiotherapy and Oncology 2020 149; 212-218
  31. Sung W; Grassberger C; McNamara AL; Basler L; Ehrbar S; Tanadini-Lang S; Hong TS and Paganetti H: A Tumor-Immune Interaction Model for Hepatocellular Carcinoma based on measured Lymphocyte Counts in Patients undergoing Radiotherapy. Radiotherapy and Oncology 2020; 151:73-81
  32. Lalonde A; Winey BA; Verburg JM; Paganetti H and Sharp GC: Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy. Physics in Medicine and Biology 2020 65; 245022
  33. Paganetti H: Commentary: “Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties”. European Journal of Medical Physics 2020 80, 274-276
  34. McClatchy DM; Willers H; Hata AN; Piotrowska Z; Sequist LV; Paganetti H and Grassberger C: Modeling Resistance and Recurrence Patterns of Combined Targeted- Chemoradiotherapy Predicts Benefit of Shorter Induction Period. Cancer Res. 2020 80, 5121-5133
  35. Niemierko A; Schuemann J; Niyazi M; Giantsoudi D; Maquilan G; Shih HA and Paganetti H. Brain necrosis in adult patients after proton therapy: Is there evidence for dependency on linear energy transfer (LET)? International Journal of Radiation Oncology, Biology and Physics 2021 109; 109-119
  36. Paganetti H; Beltran C; Both S; Dong L; Flanz J; Furutani K; Grassberger C; Grosshans DR; Knopf A-C; Langendijk JA; Nystrom H; Parodi K; Raaymakers BW; Richter C; Sawakuchi GO; Schippers M; Shaitelman SF; Teo BKT; Unkelbach J; Wohlfahrt P and Lomax T: Roadmap: Proton Therapy Physics and Biology. Physics in Medicine and Biology 2021; in press
  37. Paganetti H; Grassberger C and Sharp GC: Physics of Particle Beam and Hypofractionated Beam Delivery in NSCLC. Seminars in Radiation Oncology 2021; in press
  38. Marteinsdottir M; Wang CC; McNamara AL; Depauw N; Shin J and Paganetti H: The impact of variable RBE in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung. Physics in Medicine and Biology 2021 66, 035023
  39. Bobić M; Lalonde A; Sharp GC; Grassberger C; Verburg JM; Winey BA; Lomax AJ and Paganetti H: Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy. Physics in Medicine and Biology 2021; in press, online ahead of print
  40. Lalonde A; Bobić M; Winey B; Verburg J; Sharp GC and Paganetti H: Anatomic changes in head and neck intensity-modulated proton therapy: comparison between robust optimization and online adaptation. Radiotherapy and Oncology 2021; in press, online ahead of print
  41. Zhang YY; Huo WL; Goldberg SI; Slater JM; Adams JA; Deng XW; Sun Y; Ma J; Fullerton BC; Paganetti H; Loeffler JS; Lu HM and Chan AW: Brain-specific RBE of Protons Based on Long-term Outcome of Patients with Nasopharyngeal Carcinoma. International Journal of Radiation Oncology, Biology and Physics 2021; in press, online ahead of print
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