Harald Paganetti, PhD

Director of Physics Research
Professor
image191
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Address: Massachusetts General Hospital
Department of Radiation Oncology
100 Blossom Street
Boston, MA 02114
Phone: 617 726 5847

 

Short Curriculum Vitae

 

Director of Physics Research

Current Committee Memberships

Oversight Committee of the Harvard Medical Physics Residency Program

National Council on Radiation Protection and Measurements (NCRP)

Editorial Board: Physics in Medicine and Biology

 

Report of Scholarship

Overview:

4 Books edited

20 Book chapters

219 Peer-reviewed articles (19 sole author, 24 first author, 84 senior author)

H-index: 57

Books

“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442

“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN:  978-1-936366-43-9 2015

“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)

“Proton Therapy Physics” 2nd edition: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2018; ISBN 9781138626508

Most recent (2017-2018) publications in peer-reviewed journals

  1. Grassberger C; Scott JG and Paganetti H: Bio-mathematical Optimization of Radiation Therapy in the Era of Targeted Agents. International Journal of Radiation Oncology, Biology and Physics 2017 97; 13-17
  2. Geng C; Daartz J; Lam-Tin-Cheung K; Bussiere M; Shih H; Paganetti H and Schuemann J: Limitations of analytical dose calculations for small field proton radiosurgery. Physics in Medicine and Biology 2017 62; 246-257
  3. Giantsoudi D; Adams J; MacDonald S.M. and Paganetti H: Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for LET and Dose/Volume Parameters for the Brainstem and Organs at Risk. International Journal of Radiation Oncology, Biology and Physics 2017 97; 401-410
  4. McNamara A; Geng C; Turner R; Ramos Mendez J; Perl J; Held K; Faddegon B; Paganetti H and Schuemann J: Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Physica Medica (European Journal of Medical Physics) 2017; 33 207-216
  5. Underwood TSA; Voog JC; Moteabbed M; Tang S; Soffen E; Cahlon O; Lu H-M; Zietman AL; Efstathiou JA and Paganetti H: Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams. Acta Oncologica 2017 56; 575-581
  6. Giantsoudi D; De Man B; Verburg J; Trofimov A; Jin Y; Wang G; Gjesteby L and Paganetti H: Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction. Physics in Medicine and Biology 2017 62; R49-R80
  7. Hall DC; Trofimov AV; Winey BA; Liebsch NJ and Paganetti H: Predicting patient-specific dosimetric benefits of proton therapy for skull-base tumors using a geometric knowledge-based method. International Journal of Radiation Oncology, Biology and Physics 2017 97; 1087-1094
  8. Giantsoudi D; Seco J; Eaton BR; Simeone FJ; Kooy H; Yock TI; Tarbell NJ; DeLaney TF; Adams J; Paganetti H and MacDonald SM: Evaluating Intensity Modulated Proton Therapy relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in CSI in Growing Pediatric Patients. International Journal of Radiation Oncology, Biology and Physics 2017 98; 37-46
  9. Wei RL; Mattes MD; Yu J; Thrasher A; Shu H-K; Paganetti H; De Los Santos J; Koontz B; Abraham C and Balboni T: Attitudes of Radiation Oncologists Toward Palliative and Supportive Care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO). Practical Radiation Oncology 2017; 7 113-119
  10. Cho J; Grogg K; Min CH; Zhu X; Paganetti H and El Fakhri G: Feasibility for using 13N decay signals for PET-mediated proton range verification. Medical Physics 2017 44; 1734-1746
  11. Underwood T; Sung W; McFadden C; McMahon S; Hall D; McNamara A; Paganetti H; Sawakuchi G and Schuemann J: Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Physics in Medicine and Biology 2017 62; 3237-3249
  12. Grassberger C and Paganetti H: Varying relative biological effectiveness in proton therapy: knowledge gaps. Acta Oncologica 2017 56; 761-762
  13. Sorriaux J; Testa M; Paganetti H; Orban de Xivry J; Lee JA; Traneus E; Souris K; Vynckier S and Sterpin E: Experimental assessment of proton dose calculation accuracy in inhomogeneous media. Physica Medica 2017 38; 10-15
  14. Sung W; Ye S-J; McNamara AL; McMahon SJ; Hainfeld J; Shin J; Smilowitz HM; Paganetti H and Schuemann J: Dependence of Gold Nanoparticle Radiosensitization on Cell Geometry. Nanoscale 2017 9; 5843-5853
  15. Sorriaux J; Testa M; Paganetti H; Bertrand D; Orban de Xivry J; Lee JA; Palmans H; Vynckier S and Sterpin E: Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Medical Physics 2017 44; 4919-4927
  16. Ramos-Méndez J; Schuemann J; Incerti S; Paganetti H; Schulte R and Faddegon B: Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Physics in Medicine and Biology 2017 62; 5908-5925
  17. Kry SF; Bednarz B; Howell RM; Dauer L; Followill D; Klein E; Paganetti H; Wang B; Wuu C-S and Xu XG: AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Medical Physics 2017
  18. McMahon SJ; McNamara AL; Schuemann J; Paganetti H and Prise KM: A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Nature Scientific Reports 2017 7; 10790
  19. Manem VSK, Grassberger C, Paganetti H: Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers 2017 9; E119
  20. Tran LT; Chartier L; Bolst D; Pogossov A; Guatelli S; Petasecca M; Lerch MLF; Prokopovich DA; Reinhard MI; Clasie B; Depauw N; Kooy H; Flanz J; McNamara A; Paganetti H; Beltran C; Furutani K; Perevertaylo VL; Jackson M and Rosenfeld AB: Characterisation of proton pencil beam scanning and passive beam using a high spatial resolution solid state microdosimeter. Medical Physics 2017 44; 6085-6095
  21. Paganetti H: Relating the Proton Relative Biological Effectiveness to Tumor Control and Normal Tissue Complication Probabilities assuming Inter-patient variability in α/β. Acta Oncologica 2017 56; 1379-1386
  22. Toltz A; Hoesl M; Schuemann J; Seuntjens J; Lu HM and Paganetti H: Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification. Journal of Applied Clinical Medical Physics 2017 18; 200-205
  23. Geng C; Paganetti H and Grassberger C: Prediction of treatment response for combined chemo- and radiation therapy for non-small cell lung cancer patients using a bio-mathematical model. Nature Scientific Reports 2017 19; 13542
  24. Botas P; Grassberger C; Sharp G and Paganetti H: Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Physics in Medicine and Biology 2018 63; 035023
  25. Gentile MS; Yeap BY; Goebel C; Gaudet D; Gallotto S; Weyman E; Morgan M; MacDonald SM; Giantsoudi D; Adams J; Paganetti H; Tarbell NJ; Kooy H and Yock TI: Brainstem Injury in Pediatric Patients with Posterior Fossa Tumors Treated with Proton Beam Therapy and Associated Dosimetric Factors. International Journal of Radiation Oncology, Biology and Physics 2018 100; 719-729
  26. Haas-Kogan D; Indelicato D; Paganetti H; Esiashvili N; Mahajan A; Yock T; Flampouri S; MacDonald S; Fouladi M; Stephen S; Kalapurakal J; Terezakis S; Kooy H; Grosshans D; Makrigiorgos M; Mishra K; Young Poussaint T; Cohen K; Fitzgerald T; Gondi V; Liu A; Michalski J; Mirkovic D; Mohan R; Perkins S; Wong K; Bhadrasain V; Buchsbaum J and Larry K: National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. International Journal of Radiation Oncology, Biology and Physics 2018 101; 152-168
  27. Unkelbach J and Paganetti H: Robust Proton Treatment Planning: Physical and Biological Optimization. Seminars in Radiation Oncology 2018 28: 88–96
  28. Ramos-Mendez JA; Perl J; Schuemann J; McNamara AL; Paganetti H and Faddegon BA: Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Physics in Medicine and Biology 2018 63; 105014
  29. Giantsoudi D; Adams J; MacDonald S and Paganetti H: Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy? Acta Oncologica 2018 57; 1259-1264
  30. Paganetti H and Giantsoudi D: Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy. Seminars in Radiation Oncology 2018 28; 256-263
  31. Mohan R; Held KD; Story MD; Grosshans D; Capala J; Blakely EA; Boerma M; Bortfeld T; Chang P; Combs SE; Durante M; Formenti S; Fornace Jr AJ; Krishnan S; Limoli C; Paganetti H; Prise K; Stewart R; Tinganelli W; Timmerman R; Vikram B; Weil M and Willers H: Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology. International Journal of Radiation Oncology, Biology and Physics 2018 100; 816-831
  32. Underwood TSA; Grassberger C; Bass R; MacDonald SM; Meyersohn NM; Yeap BY; Jimenez RB and Paganetti H: Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1. International Journal of Radiation Oncology, Biology and Physics 2018 101; 809-819
  33. McNamara AL; Ramos-Mendez J; Perl J; Held K; Dominguez N; Moreno EB; Henthorn NT; Kirkby KJ; Meylan S; Villagrasa C; Incerti S; Faddegon B; Paganetti H and Schuemann J: Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Physics in Medicine and Biology 2018 63; 175018
  34. Chen Y; Grassberger C; Li J; Hong TS and Paganetti H: Impact of potentially variable RBE in liver proton therapy. Physics in Medicine and Biology 2018 63; 195001
  35. Paganetti H: Proton relative biological effectiveness - Uncertainties and opportunities. International Journal of Particle Therapy 2018 5; 2-14
  36. McMahon SJ; Paganetti H and Prise KM: LET-weighted doses effectively reduce biological variability in proton radiotherapy planning. Physics in Medicine and Biology 2018 63; 225009
  37. Tucker SL; Xu T; Paganetti H; Deist T; Verma V; Choi N; Mohan R; and Liao Z: Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk than Mean Lung Dose: Secondary Analysis of a Randomized Trial. International Journal of Radiation Oncology, Biology and Physics 2018 in press; online ahead of print
  38. Schuemann J; McNamara AL; Warmenhoven JW; Henthorn NT; Kirkby K; Merchant MJ; Ingram S; Paganetti H; Held KD; Ramos-Mendez J; Faddegon B; Perl J; Goodhead DT; Plante I; Rabus H; Nettelbeck H; Friedland W; Kundrát P; Ottolenghi A; Baiocco G; Barbieri S; Dingfelder M; Incerti S; Villagrasa C; Bueno M; Bernal MA; Guatelli S; Sakata D; Brown JMC; Francis Z; Kyriakou I; Lampe N; Ballarini F; Carante MP; Davídková M; Štěpán V; Jia X; Cucinotta FA; Schulte R; Stewart RD; Carlson DJ; Galer S; Kuncic Z; Lacombe S; Milligan J; Cho SH; Sawakuchi G; Inaniwa T; Sato T; Li W; Solov’yov AV; Surdutovich E; Durante M; Prise K and McMahon SJ: A new Standard DNA Damage (SDD) data format. Radiation Research 2018 in press; online ahead of print
  39. Durante M; Paganetti H; Pompos A; Kry SF; Wu X and Grosshans DR: Report of a National Cancer Institute Special Panel: Characterization of the Physical Parameters of Particle Beams for Biological Research. Medical Physics 20-18; in press
Located in: Leadership | Research