People Directory
Harald Paganetti, PhD

Department of Radiation Oncology
100 Blossom Street
Boston, MA 02114
https://paganetti-lab.mgh.harvard.edu/
Director of Physics Research
Current Committee Memberships
Oversight Committee of the Harvard Medical Physics Residency Program
National Council on Radiation Protection and Measurements (NCRP)
International Commission on Radiological Units and Measurements (ICRU); Report Committee 37
PTCOG-NA: Board of Directors
PTCOG: Research Proposals Sub-Committee
Executive Editorial Board: Physics in Medicine and Biology
AAPM Task Group No. 427 on “Technical Guidelines for the Use of Proton Therapy in Clinical Trials"
AAPM Task Group No. 441 on “CT based Adaptive Proton Therapy (APT): Guidelines for clinical implementation and quality management”
Report of Scholarship
Overview:
5 Books edited
26 Book chapters
316 Peer-reviewed articles (22 sole author, 31 first author, 112 senior author)
H-index: 88
Books
“Proton Therapy Physics”: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2012; ISBN-10: 1439836442
“Principles and Practice of Proton Beam Therapy”: (Eds. Indra J Das and Harald Paganetti); Medical Physics Monograph No. 37; Medical Physics Publishing, Madison, W; ISBN: 978-1-936366-43-9 2015
“Proton Beam Therapy”: Harald Paganetti; IOP Publishing 2017; ISBN: 978-0-7503-1370-4 (ebook)
“Proton Therapy Physics” 2nd edition: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2018; ISBN 9781138626508
“Proton Therapy Physics” 3rd edition: Ed. Harald Paganetti; Taylor & Francis / CRC Press 2025; in press
Publications in peer-reviewed journals in 2024 and 2025
- Huesa-Berral C; Withrow JD; Dawson RJ; Beekman C; Bolch WE; Paganetti H; Wehrenberg-Klee E and Bertolet A: MIDOS: A novel stochastic model toward a treatment planning system for Microsphere DOSimetry in liver tumors. European Journal of Nuclear Medicine and Molecular Imaging 2024 51; 1506-1515
- Bobic M; Christensen JB; Lee H; Choulilitsa E; Czerska K; Togno M; Safai S; Yukihara EG; Winey BA; Lomax AJ; Paganetti H; Albertini F and Nesteruk KP: Optically stimulated luminescence dosimeters for accurate measurement of the point dose and dose-weighted LET in adaptive proton therapy workflow. Frontiers in Oncology 2024 13; 1333039
- Moteabbed M; Bobić M; Paganetti H and Efstathiou JA: The role of proton therapy for prostate cancer in the setting of hip prosthesis. Cancers 2024 16; 330
- Pursley J; Remillard K; Depauw N; Lee G; Grassberger C; Paganetti H; Zietman AL; Efstathiou JA and Kamran SC: Radiation therapy for Stage IIA/B seminoma: modeling secondary cancer risk for protons and VMAT versus 3D photons. Cancers 2024 16; 784
- Ramos-Mendez J; Ortiz CR; Schuemann J; Paganetti H and Faddegon B: TOPAS simulation of photoneutrons in radiotherapy: accuracy and speed with variance reduction. Physics in Medicine and Biology 2024 69
- Hahn EA; Pugh SL; Lu HL; Vela AM; Gillespie EF; Nichols EM; Wright JL; MacDonald SM; Cahlon O; Baas C; Braunstein LZ; Fang LC; Freedman GM; Jimenez RB; Kesslering CM; Mishra MV; Mutter RW; Ohri N; Rosen LR; Urbanic JJ; Jagsi R; Mitchell SA; Bekelman JE; Cella D; RadComp (Radiotherapy Comparative Effectiveness Consortium). Validation of Patient-Reported Outcomes in Patients With Nonmetastatic Breast Cancer Receiving Comprehensive Nodal Irradiation in the RadComp Trial. International Journal of Radiation Oncology, Biology and Physics 2024
- Nowicka Z; Kuna K; Łaszczych M; Łazar-Poniatowska M; Sobocki BK; Stawiski K; Dąbrowski M; Bruski K; Zięba A; Pajdziński M; Staniewska E; Miszczyk M; Paganetti H; Fendler W and Tomasik B: Dosimetric prediction of radiotherapy-induced lymphocyte loss in patients with NSCLC treated with modern radiotherapy techniques. Physics and Imaging in Radiation Oncology 2024 30; 100593
- Karageorgos GM; Zhang J; Peters N; Xia W; Niu C; Paganetti H; Wang G and De Man B: A denoising diffusion probabilistic model for metal artifact reduction in CT. IEEE Transactions on Medical Imaging 2024 43; 3521-3532
- Chamseddine I; Shah K; Lee H; Ehret F; Schuemann J; Bertolet A; Shih HA and Paganetti H: Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis. Clinical Cancer Research 2024 30; 4424-4433
- Bobić M; Choulilitsa E; Lee H; Czerska K; Christensen JB; Mayor A; Safai S; Winey BA; Weber DC; Lomax AJ; Paganetti H; Nesteruk KP and Albertini F: Multi-Institutional Experimental Validation of Online Adaptive Proton Therapy Workflows. Physics in Medicine and Biology 2024 69
- Mein S; Wuyckens S; Li X; Both S; Carabe A; Chocan Vera M; Engwall E; Francesco F; Graeff C; Gu W; Hong L; Janssens G; de Jong B; Li T; Liang X; Liu G; Lomax A; Mackie T; Mairani A; Mazal A; Nesteruk K; Paganetti H; Schreuder N; Soukup M; Tessonnier T; Volz L; Zhao L and Ding X: Particle Arc Therapy: status and potential. Radiotherapy and Oncology 2024; 199: 110434
- Paganetti H; Simone II CB; Bosch WR; Haas-Kogan D; Kirsch DG; Li H; Liang X; Liu W; Mahajan A; Story MD; Taylor PA; Willers H; Xiao Y and Buchsbaum JC: NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy. International Journal of Radiation Oncology, Biology and Physics 2024 121; 202-217
- Meyer I; Peters N; Tamborino G; Lee H; Bertolet A; Faddegon B; Mille MM; Lee C; Schuemann J and Paganetti H: A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system. Physics in Medicine and Biology 2024 69
- Kunz LV; Bosque JJ; Nikmaneshi M; Chamseddine I; Munn LL: Schuemann J; Paganetti H and Bertolet A: AMBER: a modular model for tumor growth, vasculature and radiation response. Bulletin in Mathematical Biology 2024 86; 139
- Shin WG; D-Kondo JN; Ramos-Mendez J; LaVerne JA; Rothwell B; Bertolet A; McNamara A; Faddegon B; Paganetti H and SchuemannJ: Investigation of Hydrogen Peroxide Yields and Oxygen Consumption in High Dose Rate Irradiation: A TOPAS-nBio Monte Carlo Study. Physics in Medicine and Biology 2024 70
- Xing S; Correa-Alfonso CM; Shin J; Pursley J; Depauw N; Domal S; Withrow J; Bolch W; Grassberger C and Paganetti H: Evaluating the Impact of Liver Vasculature Model Complexity for Estimating Dose to Circulating Blood During Radiation Therapy. International Journal of Radiation Oncology, Biology and Physics; 2024
- Shah KD; Lee H; Soetan ZO; Yeap BY; Moteabbed M; Muise S; Cowan J; Remillard K; Silvia B; Kamran SC; Miyamoto DT; Paganetti H; Efstathiou JA and Chamseddine I: Development of a Predictive Model for Rectal Toxicity in Prostate Cancer. JCO Clinical Cancer Informatics 2025; in press
- Xiao Y; Benedict S; Cui Y; Glide-Hurst C; Graves SA; Jia X; Kry S; Li H; Lin L; Matuszak M; Newpower M; Paganetti H; Qi SX; Roncali E; Rong Y; Sgouros G; Simone II CB; Sunderland J; Taylor P; Tchelebi L; Weldon M; Zou JW; Wuthrick E; Machtay M; Le Q-T and Buchsbaum J: Embracing the Future of Clinical Trials in Radiotherapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions. International Journal of Radiation Oncology, Biology and Physics; 2025