Education

Harvard Medical Physics Residency Program     Medical Physics Resident

    Expected to complete in 07/2018

Harvard Medical School, Harvard University

Massachusetts General Hospital 2015~2017/02

Brigham and Women's Hospital         2017/02~present

ABR status completion of Part I in 2016

     Scheduled to sit for Part II in 2018 and Part III in 2019

 

Dartmouth College                                                Ph.D.

Department of Physics and Astronomy                  2010~2015

Research and Class focus: Medical Physics/Medical Imaging/Biomedical Engineering                            

Thesis – Biomedical Applications of Cherenkov Radiation Imaging during External Beam Radiation Therapy 

Primary advisors: Brian Pogue PhD, Professor, Thayer School of Engineering, Surgery, Physics & Astronomy.

David Gladstone ScD, Head of Clinical Physics, Radiation Oncology, Norris Cotton Cancer Center.

 

University of Science and Technology of China                 Physics  B.S. (Major GPA: 3.83/4.3)

Department of Physics 2006/09~2010/07

Thesis – Applications of Nitrogen Doped Defect Center in Diamond for Quantum Computing

 

Research Experience

 Medical Physics Resident         2015/07~present

• Harvard Medical Physics Residency program

• Massachusetts General Hospital

• Supervisor: Dr. Hsiao-Ming Lu

• Research project -- Single-Detector Based Proton Radiography and Proton Computed Tomography

• Research project -- Investigation of real tissue water equivalent path lengths using an efficient dose extinction method

• Research project -- Iterative Optimization of Relative Stopping Power by Single Detector Based Multi-Projectional Proton Radiography

• Supervisor: Dr. David Gierga

• Research project – Assessment of MV portal imaging for breast patients treated with surface imaging

 

 Graduate Teaching and Research Assistant       2010/09~2015/07

• Member of the Optics in Medicine Laboratory, Dartmouth College.

• Advisor: Dr. Brian W. Pogue – world leader in medical optics research

• User of Shared Irradiation Facilities, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center

• Developer of biomedical Applications of Cherenkov Radiation Imaging during External Beam Radiation Therapy, including: estimation of surface and exit dose; for accurate patient positioning; Cherenkoscopy for real time treatment monitoring; Cherenkov molecular imaging and tomography for oxygenation assessment from probe phosphorescence lifetime.

• Analyzed the relevant physical processes governing Cherenkov light emission, dose deposition and photon transportation in biological tissue using numerical models, stochastic Monte Carlo simulations, and experiments.

• Co-developed and released the first publicly available open-source Monte Carlo simulation package (GEANT4 based, C++) for radiation-induced light transport in biological media.

• Carried out first clinical trial using Cherenkov imaging in patients receiving EBRT whole breast irradiation.

• Patented the first Cherenkov imaging system during EBRT for clinical usage.

• Guided research experiences for two undergraduate students.  

• Published over 30 peer-reviewed journal articles (over 10 first-authored), a book chapter and presented research at both national and international conferences.

• Peer-reviewed over 30 papers for journals including Physics in Medicine and Biology, Medical Physics, Biomedical Optics Express, Optics Express, and Journal of Biomedical Optics, PLOS ONE, etc.

• Visited University of Birmingham and Queen Elizabeth Hospital Birmingham, UK, for research collaboration with CyberKnife.            

 

 Undergraduate Research Assistant       2008/09~2010/06

• Advisor: Guanzhong Wang

• Advanced Thin Film Lab, University of Science and Technology of China

• Hefei National Laboratory for physical sciences at the Microscale.

• Nitrogen Doped Defect Center in Diamond: Building a confocal microscopy system.

• Nitrogen Doped Defect Center in Diamond: Investigate the appellations of nitrogen doped defect center in diamond for quantum computing.

• Colorful Laser Schlieren method: An open experiment project for undergraduate students organized by the university.

• Colorful Laser Schlieren method: Analyzed the distribution of various fields (temperature field, airflow field) by using the Laser-schlieren technique; and manifested it in color image. 

 

Awards & Honors

• Candidate of The AAPM Science Council Associates Mentorship Program (2017), Mentor: Prof. Timothy C. Zhu

• Candidate of The IJROBP Resident Peer Reviewer Training (RePRT) Program

• Travelling grants from Centers of Expertise in Healthcare Quality and Patient Safety (Harvard Medical School and affiliated hospitals) to attend the 2017 National Patient Safety Foundation Congress (NPSF) to be held May 17-19 2017, Orlando, FL.

• The Reward of Science Council Session, AAPM Annual Meeting, Washington DC, (2016)

• John R. Cameron Young Investigator Competition, AAPM, Anaheim, CA, (2015)

• Graduation award for doing excellent researches, Dartmouth College, NH, (2015)

• Student Travel Stipends of WMIC meeting, 2015 World Molecular Imaging Congress meeting, Hawaii

• John R. Cameron Young Investigator Competition, AAPM, Austin, Texas, (2014)

• Best Talk, New England AAPM Young Investigators’ Symposium, Boston, MA, (2014)

• Best in Physics Imaging Award, AAPM Annual Meeting, Indianapolis, IN, (2013)

• 2010/09~2015  Dartmouth College graduate student fellowship.

• The cover of Optics & Photonics News (OPN), the Optical Society of American's official magazine, highlighted my research.

• The article -- “Optics in the Molecular Imaging Race”, published in OPN, highlighted my research.

• The article -- “Cerenkoscopy monitors breast treatments”, published on medicalphysicsweb, the official website from IOP Publishing - publishers of Physics in Medicine & Biology, highlighted my research.

• The article – “Cerenkov technique eyes linac QA”, published on medicalphysicsweb highlighted my research.

• The article – “Cerenkoscopy tested on human patient”, published on medicalphysicsweb highlighted my research.

• The article – “Cerenkov light tracks radiation dose”, published on medicalphysicsweb highlighted my research.

• The article – “Tracking oxygenation during radiotherapy”, published on medicalphysicsweb highlighted my research.

• The article – “Imaging scheme tracks tumour oxygenation”, published on medicalphysicsweb highlighted my research.

• The article – “Cerenkov imaging tracks CyberKnife therapy”, published on medicalphysicsweb highlighted my research.

• The article – “Physicists, physicians, engineers photograph radiation beams in the human body through the Cherenkov effect”, published on the homepage of Geisel school of medicine highlighted my research.

• The article – “A scientific first: Team engineers photography radiation beams in human boday through Cherenkov effect”, published on Science X (http://phys.org/), a network of high-quality websites by Facebook that provides the most complete and comprehensive daily coverage of science, technology, and medical news, highlighted my research.

• The article – “Cherenkov Emission Imaging and Spectroscopy Utilizing Isotopes and a Linear Accelerator”, published on the homepage of Princeton Instrument. The largest scientific camera and spectrometer manufacture in US, highlighted my research.

• 2008~2009      Third Prize for college physics research experiments.

• 2006~2007    Silver Scholarship of the University, only awarded to the top 5%.

• 2005~2006      Gold Prize for National Biology Contest for high school students; 

Second Prize for National Chemistry Contest for high school students.

Publications

• Journal articles

1. Rongxiao Zhang, Esther Baer, Kyung-Wook Jee, Gregory C. Sharp; Jay Flanz, Hsiao-Ming Lu. Investigation of real tissue water equivalent path lengths using an efficient dose extinction method, Phys Med Biol. 2017 Jun 23;62(14):5640-5651.

2. Brian W. Pogue, Jinchao Feng, Huiyun Lin, Petr Bruza, Ethan LaRochelle, Rongxiao Zhang, Hamid Dehghani, Scott C. Davis, Sergei Vinogradov, David J. Gladstone, Lesley A. Jarvis, High Resolution & Molecular Sensitivity Possible in Pre-Clinical Whole Body Diagnostics With Cherenkov Excited Luminescence Scanned Imaging, Nature Biomedical Engineering, (in review, 2017)

3. B.W. Pogue, R. Zhang, A.K. Glaser, J.M. Andreozzi, P. Bruza, D.J. Gladstone, L.A Jarvis, Cherenkov imaging in the potential roles of radiotherapy QA and delivery, Journal of Physics Conference Series, 2017

4. Jee, Kyung-Wook; Zhang, Rongxiao; Bentefour, El; Doolan, Paul; Cascio, Ethan; Sharp, Gregory; Flanz, Jacob; Lu, Hsiao-Ming, Investigation of time-resolved proton radiography using x-ray flat-panel imaging system, Physics in medicine and biology 62 1905-19

5. Rongxiao Zhang, Kyung-Wook Jee, Ethan Cascio, Gregory C. Sharp, Jacob Flanz, Lu, Hsiao-Ming, Improvement of Single Detector Proton Radiography based on Intensity Analysis of Time-resolved Dose Rate Function, Physics in medicine and biology (in review)

6. E. Baer, H. Bouchard, A. Lalonde, G. Royle, K.W. Jee, R. Zhang, K. Yang, G.C. Sharp, B. Liu, H.M. Lu, Experimental validation of two DECT calibration methods using real tissue samples, Medical Physics (in review)

7. Zhang R, Glaser AK, Andreozzi J, Jiang S, Jarvis LA, Gladstone DJ, et al. Beam and tissue factors affecting Cherenkov image intensity for quantitative entrance and exit dosimetry on human tissue. Journal of biophotonics. 2016.

8. Lin H, Zhang R, Gunn JR, Esipova TV, Vinogradov S, Gladstone DJ, et al. Comparison of Cherenkov excited fluorescence and phosphorescence molecular sensing from tissue with external beam irradiation. Physics in medicine and biology. 2016;61(10):3955-68.

9. Andreozzi JM, Zhang R, Gladstone DJ, Williams BB, Glaser AK, Pogue BW, et al. Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy. Medical physics. 2016;43(2):993-1002.

10. Zhang R, D'Souza A V, Gunn JR, Esipova TV, Vinogradov SA, Glaser AK, et al. Cherenkov-excited luminescence scanned imaging. Optics letters. 2015;40(5):827-30.

11. Zhang R, Andreozzi JM, Gladstone DJ, Hitchcock WL, Glaser AK, Jiang S, et al. Cherenkoscopy based patient positioning validation and movement tracking during post-lumpectomy whole breast radiation therapy. Physics in medicine and biology. 2015;60(1):L1-14.

12. Roussakis Y, Zhang R, Heyes G, Webster G, Mason S, Green S, et al. Real-time Cherenkov emission portal imaging during CyberKnife(R) radiotherapy. Physics in medicine and biology. 2015;60(22):N419-25.

13. Glaser AK, Zhang R, Andreozzi JM, Gladstone DJ, Pogue BW. Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications. Physics in medicine and biology. 2015;60(17):6701-18.

14. Glaser AK, Andreozzi JM, Zhang R, Pogue BW, Gladstone DJ. Optical cone beam tomography of Cherenkov-mediated signals for fast 3D dosimetry of x-ray photon beams in water. Medical physics. 2015;42(7):4127-36.

15. Darafsheh A, Zhang R, Kanick SC, Pogue BW, Finlay JC. Spectroscopic separation of Cerenkov radiation in high-resolution radiation fiber dosimeters. Journal of biomedical optics. 2015;20(9):095001.

16. Andreozzi JM, Zhang R, Glaser AK, Jarvis LA, Pogue BW, Gladstone DJ. Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging. Medical physics. 2015;42(2):994-1004.

17. Pogue BW, Glaser AK, Zhang R, Gladstone DJ Cherenkov radiation dosimetry in water tanks–video rate imaging, tomography and IMRT & VMAT plan verification. Journal of Physics: Conference Series; 2015: IOP Publishing. 

18. Jarvis LA, Zhang R [EQUAL CONTRIBUTION], Gladstone DJ, Jiang S, Hitchcock W, Friedman OD, et al. Cherenkov video imaging allows for the first visualization of radiation therapy in real time. International journal of radiation oncology, biology, physics. 2014;89(3):615-22.

19. Holt RW, Zhang R [EQUAL CONTRIBUTION], Esipova TV, Vinogradov SA, Glaser AK, Gladstone DJ, et al. Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies. Physics in medicine and biology. 2014;59(18):5317-28.

20. Glaser AK, Zhang R, Gladstone DJ, Pogue BW. Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose. Physics in medicine and biology. 2014;59(14):3789-811.

21. Glaser AK, Andreozzi JM, Davis SC, Zhang R, Pogue BW, Fox CJ, et al. Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation. Medical physics. 2014;41(6):062102.

22. Zhang R, Glaser AK, Gladstone DJ, Fox CJ, Pogue BW. Superficial dosimetry imaging based on Cerenkov emission for external beam radiotherapy with megavoltage x-ray beam. Medical physics. 2013;40(10):101914.

23. Zhang R, Gladstone DJ, Jarvis LA, Strawbridge RR, Jack Hoopes P, Friedman OD, et al. Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy. Journal of biomedical optics. 2013;18(11):110504.

24. Zhang R, Fox CJ, Glaser AK, Gladstone DJ, Pogue BW. Superficial dosimetry imaging of Cerenkov emission in electron beam radiotherapy of phantoms. Physics in medicine and biology. 2013;58(16):5477-93.

25. Zhang R, Davis SC, Demers JL, Glaser AK, Gladstone DJ, Esipova TV, et al. Oxygen tomography by Cerenkov-excited phosphorescence during external beam irradiation. Journal of biomedical optics. 2013;18(5):50503.

26. Glaser AK, Voigt WH, Davis SC, Zhang R, Gladstone DJ, Pogue BW. Three-dimensional Cerenkov tomography of energy deposition from ionizing radiation beams. Optics letters. 2013;38(5):634-6.

27. Glaser AK, Kanick SC, Zhang R, Arce P, Pogue BW. A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media. Biomedical optics express. 2013;4(5):741-59.

28. Glaser AK, Davis SC, Voigt WH, Zhang R, Pogue BW, Gladstone DJ. Projection imaging of photon beams using Cerenkov-excited fluorescence. Physics in medicine and biology. 2013;58(3):601-19.

29. Glaser AK, Davis SC, McClatchy DM, Zhang R, Pogue BW, Gladstone DJ. Projection imaging of photon beams by the Cerenkov effect. Medical physics. 2013;40(1):012101.

30. Demers JL, Davis SC, Zhang R, Gladstone DJ, Pogue BW. Cerenkov excited fluorescence tomography using external beam radiation. Optics letters. 2013;38(8):1364-6.

31. Zhang R, Glaser A, Esipova TV, Kanick SC, Davis SC, Vinogradov S, et al. Cerenkov radiation emission and excited luminescence (CREL) sensitivity during external beam radiation therapy: Monte Carlo and tissue oxygenation phantom studies. Biomedical optics express. 2012;3(10):2381-94.

32. Glaser AK, Zhang R, Davis SC, Gladstone DJ, Pogue BW. Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms. Optics letters. 2012;37(7):1193-5.

• Book chapter

1. Adam K. Glaser, Rongxiao Zhang, Brian W. Pogue, David J. Gladstone, “Cherenkov Imaging Applications in Radiation Therapy Dosimetry”, Scintillation Dosimetry -- Chapter 21. CRC Press LLC; 2016. ISBN 9781482208993 - CAT# K21616.

Patents

1. ZHANG R, POGUE BW, GLASER AK, GLADSTONE DJ, JARVIS LA, ANDREOZZI JM, et al. Cherenkov imaging systems and methods for determining radiation dose. Publication number WO2016176265 A1. Google Patents; 2016.

2. Pogue BW, Gladstone DJ, Davis SC, Axelsoon JJ, Glaser AK, Zhang R. Method And System For Using Cherenkov Radiation To Monitor Beam Profiles And Radiation Therapy. Publication number US20140114150 A1; WO2012159043A2; WO 2012159043 A3. Google Patents; 2014.

Conference Presentations

1. R. Zhang, K.W. Jee, G. Sharp, E. Cascio, C. Finley, J. Flanz, H.M. Lu, Iterative Optimization of Relative Stopping Power by Single Detector Based Multi-Projectional Proton Radiography, 59th AAPM annual meeting, Denver, CO, 2017 [TALK]

2. H. Wang, J. Wu, R. Zhang, E. Baer, C. Geng, K.W. Jee, G. Sharp, H. Paganetti, J. Tang, H.M. Lu, Validation of Monte-Carlo Proton Dose Calculation for Real Tissue Samples, 59th AAPM annual meeting, Denver, CO, 2017 [POSTER]

3. J. Bredfeldt, R. Zhang, E. Huynh, W. Cai, C. Williams, Y. Lyatskaya, M. Czerminska, R. Cormack, Commissioning Experience for the New Gamma Beam 500 Co-60 TBI Irradiator, 59th AAPM annual meeting, Denver, CO, 2017 [POSTER]

4. R. Zhang, K.W. Jee, G. Sharp, E. Cascio, C. Finley, J. Flanz, H.M. Lu, Proton CT using a fluoroscopy flat panel designed for X-ray imaging, PTCOG56, Japan, 2017 [POSTER]

5. K. Grogg, X. Zhu, D. Wu, K. Jee, R. Zhang, E. Baer, H Lu, G. El Fakhri, “Evaluation of Dual-Energy CT Material Characterization for PET Verification of Proton Therapy”, IEEE-MIC conference, 2016 [POSTER]

6. Zhang R, Jee K, Sharp G, Flanz J, Lu H. SU‐C‐207A‐05: Feature Based Water Equivalent Path Length (WEPL) Determination for Proton Radiography by the Technique of Time Resolved Dose Measurement. Medical physics. 2016;43(6):3325-. [TALK]

7. Zhang R, Jee K, Sharp G, Flanz J, Lu H. TU‐FG‐BRB‐10: A New Approach to Proton Radiography Using the Beamline X‐Ray Flat Panel. Medical physics. 2016;43(6):3758-. [Science Council award] [TALK]

8. Zhang R, Baer E, Jee K, Sharp G, Flanz J, Lu H. SU‐F‐J‐193: Efficient Dose Extinction Method for Water Equivalent Path Length (WEPL) of Real Tissue Samples for Validation of CT HU to Stopping Power Conversion. Medical physics. 2016;43(6):3452-. [TALK]

9. E. Bar, K.W. Jee, R. Zhang, A. Lalonde, K. Yang, G. Sharp, G. Royle, B. Liu, H. Bouchard, H.M. Lu, “Experimental validation of the DECT stoichiometric calibration for proton treatment planning using real tissue samples”, New England AAPM Young Investigators’ Symposium, Boston, MA, (2016). [TALK]

10. R. Zhang, K.W. Jee, Ethan Cascio, G. Sharp, J, Flanz, H.M. Lu, “Poor man’sproton radiography using the beamline x-ray flat panel”, New England AAPM Young Investigators’ Symposium, Boston, MA, (2016). [TALK]

11. Mason S, Roussakis Y, Zhang R, Heyes G, Webster G, Green S, et al. Cherenkov Radiation Portal Imaging during Photon Radiotherapy. Optical Tomography and Spectroscopy; 2016: Optical Society of America. [TALK]

12. A. Glaser, R. Zhang, J. Andreozzi, D. Gladstone, B. Pogue, “Cherenkov radiation fluence estimates in tissue for molecular imaging and therapy applications.” SPIE Photonics West, San Francisco, CA 2016 [POSTER]

13. Baer E, Jee K, Zhang R, Lalonde A, Yang K, Sharp G, et al. TU‐FG‐BRB‐02: The Impact of Using Dual‐Energy CT for Determining Proton Stopping Powers: Comparison Between Theory and Experiments. Medical physics. 2016;43(6):3756-. [Science Council award] [TALK]

14. Andreozzi JM, Zhang R, Glaser AK, Gladstone DJ, Jarvis LA, Pogue BW Cherenkov imaging during volumetric modulated arc therapy for real-time radiation beam tracking and treatment response monitoring. SPIE BiOS; 2016: International Society for Optics and Photonics. [POSTER]

15. Andreozzi JM, Zhang R, Glaser AK, Gladstone DJ, Jarvis LA, Pogue BW Using a reflectance-based correction on Cherenkov images to strengthen correlation with radiation surface dose in an anthropomorphic breast phantom. SPIE BiOS; 2016: International Society for Optics and Photonics. [POSTER]

16. Zhang R, Glaser A, Gladstone D, Pogue B. SU-EI-87: Calibrating Cherenkov Emission to Match Superficial Dose in Tissue. Medical physics. 2015;42(6):3262-. [POSTER]

17. Zhang R, Dsouza A, Gunn J, Esipova T, Vinogradov S, Glaser A, et al. TH-AB-204-01: Cherenkov-Excited Luminescence Scanned Imaging (CELSI) for High-Resolution, Deep-Tissue, in Vivo Optical Molecular Imaging with Limited Radiation Dose. Medical physics. 2015;42(6):3713-4. [TALK]

18. Zhang R, Andreozzi J, Gladstone D, Hitchcock W, Glaser A, Jiang S, et al. TH-AB-204-03: Cherenkov Video for Patient Positioning Validation and Movement Tracking During External Beam Radiation Therapy. Medical physics. 2015;42(6):3714-. [TALK]

19. Pogue B, Glaser A, Zhang R, Andreozzi J, Jarvis L, Gladstone D. EP-1516: Cherenkov imaging of IMRT/VMAT plans with high temporal and spatial resolution. Radiotherapy and Oncology. 2015(115):S827. [TALK]

20. Glaser A, Zhang R, Andreozzi J, Gladstone D, Pogue B. TH-AB-204-05: Real-Time Prevention of Radiation ‘mistakes’ Using Cherenkov Light Emission. Medical physics. 2015;42(6):3714-5. [TALK]

21. Darafsheh A, Zhang R, Kanick SC, Pogue BW, Finlay JC Separation of Čerenkov radiation in irradiated optical fibers by optical spectroscopy. SPIE BiOS; 2015: International Society for Optics and Photonics. [POSTER]

22. Andreozzi J, Jarvis L, Zhang R, Williams B, Glaser A, Pogue B, et al. MO-AB-BRA-08: Rapid Treatment Field Uniformity Optimization for Total Skin Electron Beam Therapy Using Cherenkov Imaging. Medical physics. 2015;42(6):3548-9. [John R. Cameron Young Investigator Competition] [TALK]

23. R. Zhang, “Molecular Imaging from Radiation Therapy”, Dartmouth-Hitchcock Medical Center, Cancer Nanotechnology Symposium: Targeting, Diagnostics & Therapy, West Lebanon, NH, (2015). [TALK]

24. R. Zhang, A. V. D'souza, J. R. Gunn, A. K Glaser, L. A. Jarvis, D. J. Gladstone and B. W. Pogue, “Cherenkov-Excited Luminescence Scanned Imaging (CELSI)”, World Molecular Imaging Congress, Honolulu, Hawaii, (2015). [TALK]

25. Zhang R, Jarvis L, Gladstone D, Andreozzi J, Hitchcock W, Jiang S, et al. In Vivo Cherenkov Video Imaging during External Beam Radiation Therapy. Biomedical Optics; 2014: Optical Society of America. [TALK]

26. Zhang R, Jarvis L, Gladstone D, Andreozzi J, Hitchcock W, Glaser A, et al. MO-A-BRD-06: In Vivo Cherenkov Video Imaging to Verify Whole Breast Irradiation Treatment. Medical physics. 2014;41(6):409-. [John R. Cameron Young Investigator Competition] [TALK]

27. Zhang R, Holt R, Esipova T, Vinogradov S, Gladstone D, Pogue B. TH-C-17A-05: Cherenkov Excited Phosphorescence Oxygen (CEPhOx) Imaging During Multi-Beam Radiation Therapy. Medical physics. 2014;41(6):554-5. [TALK]

28. Jarvis L, Zhang R, Andreozzi J, Hitchcock W, Jiang S, Pogue B, et al. Cherenkoscopy Is a Novel Imaging Technique With the Potential to Improve Accuracy and Detect Radiation Therapy Misadministrations During Whole Breast Radiation Therapy. International Journal of Radiation Oncology• Biology• Physics. 2014;90(1):S249. [TALK]

29. Holt RW, Zhang R, Esipova T, Vinogradov S, Gladstone D, Pogue BW Oxygen Imaging by Cerenkov-Excited Phosphorescence in Glioma Tumors during Radiation Therapy. Biomedical Optics; 2014: Optical Society of America. [TALK]

30. Hitchcock W, Zhang R, Gladstone D, Pogue B, Andreozzi J, Jiang S, et al. Cherenkoscopically Visualized Superficial Dose and Radiation Dermatitis During Breast Radiation Therapy. International Journal of Radiation Oncology• Biology• Physics. 2014;90(1):S237. [TALK]

31. Glaser A, Zhang R, Gladstone D, Pogue B. SU-EJ-09: A Monte Carlo Analysis of the Relationship Between Cherenkov Light Emission and Dose for Electrons, Protons, and X-Ray Photons. Medical physics. 2014;41(6):156-. [TALK]

32. R. Zhang, “In Vivo Cherenkov Video Imaging during External Beam Radiation Therapy”, New England AAPM Young Investigators’ Symposium, Boston, MA, (2014). [Best Talk]

33. Glaser A, Zhang R, Fox C, Gladstone D, Pogue BW Video-rate optical dosimetry of dynamic radiotherapy plans by the Cherenkov effect. Biomedical Optics; 2014: Optical Society of America. [TALK]

34. R. Zhang, L. Jarvis, D. Gladstone, J. Andreozzi1, W. Hitchcock, S. Jiang, A. Glaser, B. Pogue, “Cherenkov Radiation Eyes External Beam Radiation Therapy”, Norris Cotton Cancer Center, Radiation Oncology Symposium, West Lebanon, NH, (2014). [TALK]

35. Glaser A, Zhang R, Andreozzi J, Davis S, Fox C, Gladstone D, et al. TH-C-17A-03: Dynamic Visualization and Dosimetry of IMRT and VMAT Treatment Plans by Video-Rate Imaging of Cherenkov Radiation in Pure Water. Medical physics. 2014;41(6):554-. [TALK]

36. J. Andreozzi, R. Zhang, A. Glaser, L. Jarvis, D. Gladstone, B. Pogue, “Camera selection fro real-time verification system using Cherenkov imaging”, , New England AAPM Young Investigators’ Symposium, Boston, MA, (2014). [TALK]

37. Glaser A, Kanick S, Zhang R, Pogue BW GEANT4-a new and robust tool for biophotonics Monte Carlo simulations. Biomedical Optics; 2014: Optical Society of America. [TALK]

38. Andreozzi J, Zhang R, Glaser A, Jarvis L, Gladstone D, Pogue B. TH-C-17A-01: Imaging Sensor Comparison for Real-Time Cherenkov Signal Detection From Tissue for Treatment Verification. Medical physics. 2014;41(6):553-4. [TALK]

39. Zhang R, Fox C, Jarvis L, Glaser A, Gladstone D, Pogue B. TH‐A‐141‐09: BEST IN PHYSICS (IMAGING)—Superficial Dose Imaging Based On Cherenkov Radiation Emission During Megavoltage External Beam Radiotherapy. Medical physics. 2013;40(6):524-. [TALK]

40. B. Pogue, R. Zhang, S. Davis, A. Glaser, S. A. Vinogradov, D. Gladstone, L. Jarvis, “Cerenkov emission in radiation therapy to estimate skin dose and monitor tissue oxygenation,” World Molecular Imaging Congress, Savannah, GA, (2013). [TALK]

41. Glaser A, Davis S, Zhang R, Gladstone D, Pogue B. WE‐E‐141‐11: Optical Cone Beam 3D Tomography of Radiation Beams Using Cerenkov‐Excited Fluorescence. Medical physics. 2013;40(6):493-. [TALK]

42. R. Zhang, A. Glaser, T. Esipova, S. Vinogradov, D. Gladstone, B. Pogue, “Oxygenation quantification based on Cerenkov radiation excited luminescence (CREL),” Joint Workshop: Technology for Innovation in Radiation Oncology, National Institute of Health, Bethesda, (2013). [POSTER]

43. R. Zhang, A. Glaser, C. Fox, D. Gladstone, L. Jarvis, B. Pogue, “Superficial Dosimetry Imaging Based on Cerenkov Radiation for Megavoltage External Beam Radiotherapy,” Joint Workshop: Technology for Innovation in Radiation Oncology, National Institute of Health, Bethesda, (2013). [TALK]

44. Zhang R, Kanick S, Vinogradov S, Esipova T, Pogue B. SU‐E‐I‐94: External Beam Radiation Cherenkov Emission in Tissue Used for Tissue Oxygen Sensing. Medical physics. 2012;39(6):3646-7. [TALK]

45. Zhang R, Glaser A, Davis S, Gladstone D, Pogue B Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms. Biomedical Optics; 2012: Optical Society of America. [TALK]

46. Glaser A, Axelsson J, Zhang R, Gladstone D, Pogue B Cherenkov emission spectroscopy for tissue oxygen saturation assessment. Biomedical Optics; 2012: Optical Society of America. [TALK]

47. R. Zhang, A. Glaser, T. Esipova, S. Kanick, S. Davis, S. Vinogradov, D. Gladstone, B. Pogue, “Application of Čerenkov Radiation for Oxygenation and Surface Dose Assessment during External Beam Radiotherapy,” American Association of Physicists in Medicine Meeting, Charlotte, NC, (2012). [TALK]

Funding

Fluorescence Imaging to Optimize Cancer Therapy
R01 CA109558 (PI B. Pogue)  09/11 – 07/16 
NIH/NCI $169,195
This was focused on analyzing how molecular tracers of glioma tumors could be used to effectively quantify tumor microenvironment.  Funding from this grant was used to prototype the initial Cherenkov imaging camera system.

Imaging surface dose in post lumpectomy whole breast irradiation
Audrey Prouty Breast Cancer Research Grant (PIs L. Jarvis, D. Gladstone & B. Pogue) 04/13-03/14
Norris Cotton Cancer Center Pilot Funds   $50,000
This pilot grant fund was used for testing and pilot phase clinical trial studies imaging skin dose during whole breast radiation therapy funding the major part of thesis work in this area.

Cerenkov Tomography of 4D Radiation Therapy Plans
R21 EB017559 (PIs B. Pogue & D. Gladstone)  09/13 – 08/15  
NIH/NIBIB      $150,000
The focus of this work was prototyping and testing an optical tomography system for imaging radiation treatment plans for IMRT in water tanks.

Affiliations & Activities

• 2017~present    The AAPM Science Council Associates Mentorship Program    Mentor: Prof. Timothy C. Zhu

• 2017~present    Guest on the Treatment delivery sub-committee of AAPM

• 2017~present    The IJROBP Resident Peer Reviewer Training (RePRT) Program

• 2014~present                 AAPM membership.

• 2014~present                 OSA (The Optical Society of American) membership.

• 2015~present                WMIC membership.

• 2010~present                 Dartmouth Graduate Student Fellowship.

• 2012~present                 Reviewed over 30 papers for Medical Physics, Physics in Medicineand Biology, Radiation Oncology, Physica Medica, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment,  Journal of Biomedical Optics, Optics Express, Biomedical Optics Express.

• 2014/08~2014/09          Visited University of Birmingham and Queen Elizabeth Hospital Birmingham, UK, for research collaboration with CyberKnife.            

• 2014/02~2014/03       SLAC Geant4 Tutorial 2014, Stanford University, Palo Alto, CA, USA

Skills & Interests

• Proficient in Matlab, LaTeX, mathematical modeling and machine learning.
• Good at UNIX, Linux Shell, C programming language, C++, FORTRAN and R.
• Working knowledge of LabView, Mathematica and HTML.
• Languages – English (completely fluent), Chinese (native), French and Japanese (amateur).
• Interests – Reading, Charcoal drawing, Photography, Cooking, Hiking, Badminton, Ping-Pong.