Current Positions

Medical Physicist, Massachusetts General Hospital

Instructor, Department of Radiation Oncology, Harvard Medical School

Past Experience

Resident, Harvard Medical Physics Residency Program, Boston, MA 2018-2021

Clinical Research Fellow, Radiation-Drug Treatment Design Lab (Advisors: Grassberger & Paganetti), MGH, Boston, MA, 2018-2019

Education

Ph.D., Engineering Sciences, Thayer School of Engineering, Dartmouth College, Hanover, NH, 2018

• Completed CAMPEP Accredited Medical Physics Education Program
• Dissertation: “Development and Translation of Light Scatter Imaging and micro-Computed Tomography to Improve the Surgical Resection of Breast Cancer”
• Advisor: Prof. Brian Pogue, Ph.D.

A.B., Engineering Sciences, Dartmouth College, Hanover, NH, 2013

• Awarded Departmental High-Honors

Grants and Awards

• Associate of the Science Council Associate Mentorship Program (SCAMP), AAPM, 2019
• Early Career Fellowship, Winter Institutes of Medical Physics (WIMP), 2019
• F31 Pre-Doctoral National Research Service Award, NIH/NCI, 2016-2018
• John W. Strohbehn, PhD Memorial Prize, Thayer School of Engineering, 2018
• Travel Grant Recipient, The Neukom Institute for Computational Science, 2014

• Travel Fellowship, UC Irvine National Short Course in Computational Biophotonics, 2013
• Kaminsky Family Fund Award Grant, Dartmouth College Office of Undergraduate Research, 2013
• John C. Woodhouse Engineering Design Prize, Thayer School of Engineering, 2012

• Page Worthington Scholarship Fund, Dartmouth Club of Maryland, 2010

Patents

1. Stephen C. Kanick, Brian W. Pouge, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy III, Venkatramanan Krishnaswamy. ”Structured-Light Imaging Systems and Methods for Determining Sub-Diffuse Scattering Parameters”, Application Filed February 2016, Granted November 2019 US 10,463,256 B2 
2. Venkatramanan Krishnaswamy, Brian W. Pouge, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy III. ”Apparatus and Methods for Structured Light Scatteroscopy”, Application Filed February 2015, Granted November 2019, US 10,485,425 B2
3. Jay Vincelli, David McClatchy, Stephanie Wolf, Ryan Halter, James Yun, ”Miniaturized Cardiopulmonary Bypass Circuit for a Mouse Model”, Application Filed February 2014, Granted February 2017, US 9,561,315 B1

Publications

1. Kamran SC*, McClatchy DM 3rd*, Pursley J, Trofimov AV, Remillard K, Saraf A, Ghosh A, Thabet A, Sutphin P, Miyamoto DT, and Efstathiou JA. "Characterization of an Iodinated Rectal Spacer for Prostate Photon and Proton Radiotherapy," Pract Radiat Oncol. 2021 DOI: 10.1016/j.prro.2021.09.009. * Denotes Equal Contribution  .
2. Pardo A, Streeter SS, Maloney BW, Gutierrez-Gutierrez JA, McClatchy DM, Wells WA, Paulsen KD, Lopez-Higuera JM, Pogue BW, Conde OM. "Modeling and Synthesis of Breast Cancer Optical Property Signatures With Generative Models," IEEE Trans Med Imaging. 2021 06; 40(6):1687-1701.
3. McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C. "Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period," Cancer Res. 2020 11 15; 80(22):5121-5133. 
4. Streeter, S.S., Maloney, B.W., McClatchy, III, D. M., Pogue, B. W., Rizzo, E. J. , Wells, W. A., and Paulsen, K. D., “Structured light imaging for breast-conserving surgery, part II: texture analysis and classification,” Journal of Biomedical Optics 24(9), 096003 (2019). DOI: 10.1117/1.JBO.24.9.096003
5. Maloney, B.W., Streeter, S.S., McClatchy, III, D. M., Pogue, B. W., Rizzo, E. J. , Wells, W. A., and Paulsen, K. D., “Structured light imaging for breast-conserving surgery, part I: optical scatter and color analysis,” Journal of Biomedical Optics 24(9), 096002 (2019). DOI: 10.1117/1.JBO.24.9.096002, Featured on Cover
6. Grassberger, C.*, McClatchy, III, D. M.*, Geng, C., Kamran, C. K., Fintelmann, F., Maruvka, Y. E., Piotrowska, Z., Willers, H., Sequist, L. V., Hata, A., Paganetti, H., “Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies,” Cancer Research 79(14), 3776-3788 (Jul 2019). DOI: 10.1158/0008-5472.CAN-18-3652. *co-corresponding authors
7. Maloney, B.W., McClatchy, III, D. M., Pogue, B. W., Paulsen, K. D., W. A., and Barth, Jr., R.J., “Review of Methods for Intraoperative Margin Detection for Breast Conserving Surgery,” Journal of Biomedical Optics 23(10), 100901 (2018). DOI: 10.1117/1.JBO.23.10.100901
8. McClatchy, III, D. M., Zuurbier, R. A., Wells, W. A., Paulsen, K. D., and Pogue, B. W., “Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro- CT readings to final histopathology,” Breast Cancer Research and Treatment, 1–9 (2018). DOI: 10.1007/s10549-018-4951-3
9. McClatchy, III, D. M., Rizzo, E. J., Kanick, S. C., Wells, W. A., Black, C. C., Paulsen, K. D., and Pogue, B. W., “Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue,” Journal of Biomedical Optics 24(7), 071605 (2018). DOI: 10.1117/1.JBO.24.7.071605
10. McClatchy, III, D. M., Rizzo, E. J., Meganck, J., Kemper, J., Vicory, J., Wells, W. A., Paulsen, K. D., and Pogue, B. W., “Calibration and analysis of a multimodal micro-CT and structured light imaging system for the evaluation of excised breast tissue,” Physics in Medicine and Biology 62(23), 8983 (2017). DOI: 10.1088/1361-6560/aa94b6
11. Carlson, M. L., McClatchy, III, D. M., Gunn, J., Elliott, J. T., Paulsen, K. D., Kanick, S. C., and Pogue, B. W., “Wide-field color imaging of scatter-based tis- sue contrast using both high spatial frequency illumination and cross-polarization gating,” Journal of Biophotonics 10, 1864–0648 (2017). DOI: 10.1002/jbio.201700104
12. McClatchy, D. M., Hoopes, P. J., Pogue, B. W., and Kanick, S. C., “Monochromatic subdiffusive spatial frequency domain imaging provides in-situ sensitivity to intratumoral morphological heterogeneity in a murine model,” Journal of Biophotonics 10(2), 211–216 (2017). DOI: 10.1002/jbio.201600181, Featured on Back Cover
13. McClatchy, D. M., Rizzo, E. J., Wells, W. A., Cheney, P. P., Hwang, J. C., Paulsen, K. D., Pogue, B. W., and Kanick, S. C., “Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging,” Optica 3, 613–621 (Jun 2016). DOI: 10.1364/OPTICA.3.000613
14. McClatchy, III, D. M., Krishnaswamy, V., Kanick, S. C., Elliott, J. T., Wells, W. A., Barth, Jr., R. J., Paulsen, K. D., and Pogue, B. W., “Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical as- sessment during breast conserving surgery,” Journal of Biomedical Optics 20(4), 040504 (2015). DOI: 10.1117/1.JBO.20.4.040504
15. Kanick, S. C., McClatchy, D. M., Krishnaswamy, V., Elliott, J. T., Paulsen, K. D., and Pogue, B. W., “Sub-diffusive scattering parameter maps recovered using wide-field high-frequency structured light imaging,” Biomedical Optics Express 5, 3376–3390 (Oct 2014). DOI: 10.1364/BOE.5.003376
16. Krishnaswamy, V., Elliott, J. T., McClatchy, III, D. M., Barth, Jr., R. J., Wells, W. A., Pogue, B. W., and Paulsen, K. D., “Structured light scatteroscopy,” Journal of Biomedical Optics 19(7), 070504 (2014). DOI: 10.1117/1.JBO.19.7.070504
17. Sexton, K., Davis, S. C., McClatchy, D., Valdes, P. A., Kanick, S. C., Paulsen, K. D., Roberts, D. W., and Pogue, B. W., “Pulsed-light imaging for fluorescence guided surgery under normal room lighting,” Optics Letters 38, 3249–3252 (Sep 2013). DOI: 10.1364/OL.38.003249
18. Glaser, A. K., Davis, S. C., McClatchy, D. M., Zhang, R., Pogue, B. W., and Gladstone, D. J., “Projection imaging of photon beams by the Cˇerenkov effect,” Medical Physics 40(1), 012101 (2013). DOI: 10.1118/1.4770286