Short bio: Sarah Johnstone is a physician-scientist and principle investigator at the Dana Farber Cancer Institute.  She obtained her Ph.D. in genetics from the Massachusetts Institute of Technology where she studied transcriptional regulatory circuitry in early development in the lab of Dr. Richard Young.  Following her doctoral training, she obtained an M.D. at the Johns Hopkins School of Medicine where she also performed research on DNA methylation in cancer in the lab of Dr. Steve Baylin.  Following her degrees, she completed a residency in Anatomic Pathology and a fellowship in Gynecologic Pathology at the Massachusetts General Hospital (MGH) Department of Pathology.  Her post-doctoral work in the lab of Dr. Bradley Bernstein at MGH described the first global topological maps in primary tumors and demonstrated the link between large-scale compartment shifts, DNA methylation and tumor suppressive transcriptional programs.  She recently joined the Dana Farber as a principle investigator and the Department of Pathology at the Brigham and Women’s Hospital.  Her laboratory studies how epigenetic and topological structures changes in cancer and the impact of these changes on tumor phenotype.