The Langenau Laboratory research focus is to uncover relapse mechanisms in pediatric cancer. Utilizing zebrafish models of embryonal rhabdomysoarcoma (ERMS) and T-cell acute lymphoblastic leukemia (T-ALL), they have undertaken chemical and genetic approaches to identify novel modulators of progression, therapy-resistance and relapse. New approaches to visualize human cancers grown in zebrafish when complexed with a wide array of novel imaging approaches are uncovering new biology and mechanisms of therapy response that translate directly to the clinic.