Physical dose conformation
We explore and develop radiation treatment techniques for optimum physical dose conformation to the tumor target volume. Our efforts are focused on proton radiotherapy and advanced photon treatments, as well as on their comparison.
As a basis for treatment optimization we work on a variety of modeling projects including relative biological effectiveness in proton therapy, outcome models for the relationship between the dose distribution and clinical outcome, and spatial modeling of microscopic disease for gliomas.
Intensity modulation is crucial both in photonradiotherapy (IMXT) and in proton radiotherapy (IMPT). In particular, we develop robust optimization methods for handling uncertainty in IMPT, direct aperture optimization algorithms, VMAT plan optimization, and multi-criteria planning methods.
We develop concepts and methods to consider the time component in the whole radiotherapy chain, from imaging over planning and optimization to treatment delivery.
To increase the precision of the dose application we develop new targeting techniques. To increase the accuracy of the dose prediction we perform Monte Carlo simulations.
TIP program started!
Physics Awards in 2014
3rd Most Downloaded Paper from Physics in Medicine and Biology in 2014
Review on the characteristics of radiation detectors for dosimetry and imaging
Joao Seco, Ben Clasie and Mike Partridge
Selected from the ASTRO meeting for 2014 Best of ASTRO
Abstract Title: Site-Specific Range Uncertainties Due to by Dose Calculation Algorithms for Proton Therapy Link to the article.
Authors: J Schuemann, S Dowdell, C Grassberger, C H Min and H Paganetti
The PMB featured article is here.
At the ESTRO conference in Vienna, Austria, Christian Richter won the Young Scientists Poster Award in physics for his work "Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism", which he did as a research fellow at MGH. Christian is now back at OncoRay Dresden, Germany.
Authors: Christian Richter*, Joao Seco, Dan Duda, Thomas Bortfeld
Videos about our work published on physicsworld.com
1. A pioneering approach to cancer treatment
2. Targeting tumours
3. Proton therapy teams up with PET imaging
4. Fighting cancer with mathematics
Recent papers featured on MedicalPhysicsWeb
November 2013: IMPT: Addressing Range Uncertainties [Link]
November 2013: Resolving gamma lines verify proton range [Link]
September 2013: The Expanding Roles of Medical Physicists [Link]
June 2013: Resolvable gammas boost range verification [Link]
April 2013: Monte Carlo techniques in radiation therapy [Link]
April 2013: Limiting interplay effects in proton therapy [Link]
April 2013: In-room PET treatment verification [Link]
January 2013: The interdependence of optimal fractionation schemes and the spatial dose distribution. [Link]
January 2013: The generalization of direct aperture optimization methods to a mult-criteria planning framework. [Link]
December 2012: GPU accelerates proton dose calculations [Link]
May 2012: Reducing out-of-field doses in scanning proton therapy using apertures. [Link]
February 2012: MCO VMAT. [Link]
January 2012: MCO-Robust IMPT planning. [Link]
New: Books by Joao Seco and Harald Paganetti
Monte Carlo Techniques in Radiation Therapy
Publication Date: March 21, 2013
Proton Therapy Physics
Publication Date: December 14, 2011