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Physics Research

Imaging

Simulation

Multicriteria Optimization

Robust Optimization

Protons

Physics Division

Physical dose conformation

We explore and develop radiation treatment techniques for optimum physical dose conformation to the tumor target volume. Our efforts are focused on proton radiotherapy and advanced photon treatments, as well as on their comparison.

Biological modeling

As a basis for treatment optimization we work on a variety of modeling projects including relative biological effectiveness in proton therapy, outcome models for the relationship between the dose distribution and clinical outcome, and spatial modeling of microscopic disease for gliomas.

IMXT/IMPT

Intensity modulation is crucial both in photonradiotherapy (IMXT) and in proton radiotherapy (IMPT). In particular, we develop robust optimization methods for handling uncertainty in IMPT, direct aperture optimization algorithms, VMAT plan optimization, and multi-criteria planning methods.

4D

We develop concepts and methods to consider the time component in the whole radiotherapy chain, from imaging over planning and optimization to treatment delivery.

Precision

To increase the precision of the dose application we develop new targeting techniques. To increase the accuracy of the dose prediction we perform Monte Carlo simulations.

Videos about our work published on physicsworld.com

These videos were published by the Institute of Physics (physicsworld) in March 2013:

1. A pioneering approach to cancer treatment

http://physicsworld.com/cws/article/multimedia/2013/mar/14/a-pioneering-approach-to-cancer-treatment

2. Targeting tumours

http://physicsworld.com/cws/article/multimedia/2013/mar/21/targeting-tumours

3. Proton therapy teams up with PET imaging

http://physicsworld.com/cws/article/multimedia/2013/mar/21/proton-therapy-teams-up-with-pet-imaging

4. Fighting cancer with mathematics

http://physicsworld.com/cws/article/multimedia/2013/mar/27/fighting-cancer-with-mathematics

Harald Paganetti won the 2012-2013 A. Clifford Barger Excellence in Mentoring Award

The award is given to those who have given exceptional sponsorship, encouragement and support for the career and/or personal development of other faculty, trainees, and students at Harvard Medical School.

More information: http://www.mfdp.med.harvard.edu/awards/mentoring/index.html