Physical dose conformation
We explore and develop radiation treatment techniques for optimum physical dose conformation to the tumor target volume. Our efforts are focused on proton radiotherapy and advanced photon treatments, as well as on their comparison.
As a basis for treatment optimization we work on a variety of modeling projects including relative biological effectiveness in proton therapy, outcome models for the relationship between the dose distribution and clinical outcome, and spatial modeling of microscopic disease for gliomas.
Intensity modulation is crucial both in photonradiotherapy (IMXT) and in proton radiotherapy (IMPT). In particular, we develop robust optimization methods for handling uncertainty in IMPT, direct aperture optimization algorithms, VMAT plan optimization, and multi-criteria planning methods.
We develop concepts and methods to consider the time component in the whole radiotherapy chain, from imaging over planning and optimization to treatment delivery.
To increase the precision of the dose application we develop new targeting techniques. To increase the accuracy of the dose prediction we perform Monte Carlo simulations.
TIP program started!
Physics Awards in 2015
May 20, 2015: Joost Verburg, PhD defended his PhD thesis "Reducing Range Uncertainty in Proton Therapy" at the University of Eindhoven, the Netherlands. Congratulations!
May 23, 2015: Jay Flanz, PhD was elected the new Chairman of the Particle Therapy Co-Operative Group (PTCOG) at the PTCOG meeting in San Diego. Congratulations on this great recognition of Jay's contributions to our field!
May 26, 2015: With Bruce Crawford, MS and the Proton Engineering Staff we had two physics honorees among The One Hundred. Congratulations on this outstanding and well deserved honor!
June 25, 2015: Thomas Bortfeld, PhD was awarded the Alfred Breit Preis of the German Society for Radiation Oncology (DEGRO). The Breit Preis is the highest award of the DEGRO and Thomas is the first physicist who received this award (undivided). Congratulations!
Videos about our work published on physicsworld.com
1. A pioneering approach to cancer treatment
2. Targeting tumours
3. Proton therapy teams up with PET imaging
4. Fighting cancer with mathematics
Recent papers featured on MedicalPhysicsWeb
May 2015: Improving PET monitoring of proton therapy [Link]
January 2015: Nanoparticles boost proton dose. [Link]
April 2014: Horizons 2013: Connecting physicists in medicine. [Link]
November 2013: IMPT: Addressing Range Uncertainties [Link]
November 2013: Resolving gamma lines verify proton range [Link]
September 2013: The Expanding Roles of Medical Physicists [Link]
June 2013: Resolvable gammas boost range verification [Link]
April 2013: Monte Carlo techniques in radiation therapy [Link]
April 2013: Limiting interplay effects in proton therapy [Link]
April 2013: In-room PET treatment verification [Link]
January 2013: The interdependence of optimal fractionation schemes and the spatial dose distribution. [Link]
January 2013: The generalization of direct aperture optimization methods to a mult-criteria planning framework. [Link]
December 2012: GPU accelerates proton dose calculations [Link]
May 2012: Reducing out-of-field doses in scanning proton therapy using apertures. [Link]
February 2012: MCO VMAT. [Link]
January 2012: MCO-Robust IMPT planning. [Link]