Physical dose conformation
We explore and develop radiation treatment techniques for optimum physical dose conformation to the tumor target volume. Our efforts are focused on proton radiotherapy and advanced photon treatments, as well as on their comparison.
As a basis for treatment optimization we work on a variety of modeling projects including relative biological effectiveness in proton therapy, outcome models for the relationship between the dose distribution and clinical outcome, and spatial modeling of microscopic disease for gliomas.
Intensity modulation is crucial both in photonradiotherapy (IMXT) and in proton radiotherapy (IMPT). In particular, we develop robust optimization methods for handling uncertainty in IMPT, direct aperture optimization algorithms, VMAT plan optimization, and multi-criteria planning methods.
We develop concepts and methods to consider the time component in the whole radiotherapy chain, from imaging over planning and optimization to treatment delivery.
To increase the precision of the dose application we develop new targeting techniques. To increase the accuracy of the dose prediction we perform Monte Carlo simulations.
Physics Awards in 2014
3rd Most Downloaded Paper from Physics in Medicine and Biology in 2014
Review on the characteristics of radiation detectors for dosimetry and imaging
Joao Seco, Ben Clasie and Mike Partridge
Selected from the ASTRO meeting for 2014 Best of ASTRO
Abstract Title: Site-Specific Range Uncertainties Due to by Dose Calculation Algorithms for Proton Therapy Link to the article.
Authors: J Schuemann, S Dowdell, C Grassberger, C H Min and H Paganetti
The PMB featured article is here.
At the ESTRO conference in Vienna, Austria, Christian Richter won the Young Scientists Poster Award in physics for his work "Radiation-induced changes in hepatocyte-specific Gd-EOB-DTPA enhanced MRI: Potential mechanism", which he did as a research fellow at MGH. Christian is now back at OncoRay Dresden, Germany.
Authors: Christian Richter*, Joao Seco, Dan Duda, Thomas Bortfeld
Physics Awards in 2013
Stephen Dowdell received one of two annual AAPM Seed Funding Grants ($25,000 of re-search funding).
Authors: C. Grassberger*, S. Dowdell, G. Sharp, H. Paganetti
Authors: J Unkelbach*, C Zeng, M Engelsman
- Clasie B M, Sharp G C, Seco J, Flanz J B and Kooy H M 2012 "Numerical solutions of the gamma index in two and three dimensions" Phys. Med. Biol. 57 6981
Videos about our work published on physicsworld.com
1. A pioneering approach to cancer treatment
2. Targeting tumours
3. Proton therapy teams up with PET imaging
4. Fighting cancer with mathematics
Harald Paganetti won the 2012-2013 A. Clifford Barger Excellence in Mentoring Award
The award is given to those who have given exceptional sponsorship, encouragement and support for the career and/or personal development of other faculty, trainees, and students at Harvard Medical School.
More information: http://www.mfdp.med.harvard.edu/awards/mentoring/index.html