Physical dose conformation
We explore and develop radiation treatment techniques for optimum physical dose conformation to the tumor target volume. Our efforts are focused on proton radiotherapy and advanced photon treatments, as well as on their comparison.
As a basis for treatment optimization we work on a variety of modeling projects including relative biological effectiveness in proton therapy, outcome models for the relationship between the dose distribution and clinical outcome, and spatial modeling of microscopic disease for gliomas.
Intensity modulation is crucial both in photonradiotherapy (IMXT) and in proton radiotherapy (IMPT). In particular, we develop robust optimization methods for handling uncertainty in IMPT, direct aperture optimization algorithms, VMAT plan optimization, and multi-criteria planning methods.
We develop concepts and methods to consider the time component in the whole radiotherapy chain, from imaging over planning and optimization to treatment delivery.
To increase the precision of the dose application we develop new targeting techniques. To increase the accuracy of the dose prediction we perform Monte Carlo simulations.
Therapy Imaging Program (TIP)
Supported by Federal Share of program income earned by MGH on C06 CA059267
(T. Bortfeld, G. El Fakhri, R. Jeraj)
To achieve the best proton therapy treatment through advanced imaging.
To support NCI proton therapy clinical trials at MGH and elsewhere using imaging as a biomarker.
Physics Awards in 2015
July 24, 2015: Yang Kyun Park PhD, Justin Phillips PhD, Greg Sharp PhD and Brian Winey PhD were honored as "Editor's Pick", "Featured Article" and Cover Image for their publication "Proton dose calculation on scatter-corrected CBCT image: Feasibility study for adaptive proton therapy" in the August 2015 edition of Medical Physics.
July 13, 2015: Joost Verburg, PhD received the 3rd place Young Investigator Award 2015 from the American Association of Physicists in Medicine (AAPM) for his presentation "Prompt Gamma-Ray Spectroscopy for Range Verification of Clinical Proton Beams". Co-authors: J. Verburg, T. Bortfeld, J. Seco. Top 3 out of more than 300 submissions for this competition.
June 25, 2015: Thomas Bortfeld, PhD was awarded the Alfred Breit Preis of the German Society for Radiation Oncology (DEGRO). The Breit Preis is the highest award of the DEGRO and Thomas is the first physicist who received this award (undivided). Congratulations!
May 26, 2015: With Bruce Crawford, MS and the Proton Engineering Staff we had two physics honorees among The One Hundred. Congratulations on this outstanding and well deserved honor!
May 23, 2015: Jay Flanz, PhD was elected the new Chairman of the Particle Therapy Co-Operative Group (PTCOG) at the PTCOG meeting in San Diego. Congratulations on this great recognition of Jay's contributions to our field!
May 20, 2015: Joost Verburg, PhD defended his PhD thesis "Reducing Range Uncertainty in Proton Therapy" at the University of Eindhoven, the Netherlands. Congratulations!
Videos about our work published on physicsworld.com
1. A pioneering approach to cancer treatment
2. Targeting tumours
3. Proton therapy teams up with PET imaging
4. Fighting cancer with mathematics
Recent papers featured on MedicalPhysicsWeb
November 2015: Nanoparticles target tumor vasculature [Link]
May 2015: Improving PET monitoring of proton therapy [Link]
January 2015: Nanoparticles boost proton dose [Link]
April 2014: Horizons 2013: Connecting physicists in medicine [Link]
November 2013: IMPT: Addressing Range Uncertainties [Link]
November 2013: Resolving gamma lines verify proton range [Link]
September 2013: The Expanding Roles of Medical Physicists [Link]
June 2013: Resolvable gammas boost range verification [Link]
April 2013: Monte Carlo techniques in radiation therapy [Link]
April 2013: Limiting interplay effects in proton therapy [Link]
April 2013: In-room PET treatment verification [Link]
January 2013: The interdependence of optimal fractionation schemes and the spatial dose distribution [Link]
January 2013: The generalization of direct aperture optimization methods to a mult-criteria planning framework [Link]
December 2012: GPU accelerates proton dose calculations [Link]
May 2012: Reducing out-of-field doses in scanning proton therapy using apertures [Link]
February 2012: MCO VMAT [Link]
January 2012: MCO-Robust IMPT planning [Link]