Clemens Grassberger, PhD

Head of the Radiation-Drug Treatment Design Lab
Assistant Professor, Harvard Medical School and MGH
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E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 617 724 1202

Education and Degrees

current:
Assistant Professor in Radiation Oncology, Harvard Medical School and Massachusetts General Hospital

Postdoctoral Fellowship: Harvard Medical School and MGH, 2014-2016

PhD Physics: Eidgenössische Technische Hochschule Zürich, Switzerland, 2014

BSc Physics ETH: Eidgenössische Technische Hochschule Zürich, Switzerland, 2008

Foreign Stipendiary: Ecole Normale Superieure Paris, France, 2009

MSc Physics ETH: Eidgenössische Technische Hochschule Zürich, Switzerland, 2010

Awards & Honors

2016 Winner – CHEST Foundation Research Grant in Lung Cancer 2016
2016 Winner – Young Investigator Award, Clinical Track – ASTRO 2016
2015 - 1st place in team competition at the Integrated Mathematical Oncology workshop at Moffitt Cancer Center
2013 AAPM Young Investigator Award, 2nd place

Areas of Interest

  • Exploring rational combinations between various immunotherapeutic approaches and radiotherapy 
  • Lymphocyte cell populations as markers of treatment response 
  • Modeling interactions of biological agents & chemotherapy with radiation 
  • Modeling resistance development to tyrosine kinase inhibitors in EGFR-mutant Non-Small Cell Lung Cancer
  • Investigating Fluorothymidine-PET during treatment as biomarker for response  
  • Hepatic normal tissue toxicity in HCC and ICC patients treated with radiation
Project Opportunities: If you’re interested in working on these or related questions, have a look at our list of open projects --> here
 

Clemens Grassberger on PubMed

Publications

Geng C, Paganetti H, Grassberger C. Prediction of Treatment Response for Combined Chemo-and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Scientific Reports. 2017 Oct 19;7(1):13542.

For a 3-minute explanation of this investigation, watch this video recorded at ASTRO 2017 on the website of the National Comprehensive Cancer Network: https://jnccn360.org/nsclc/videos/nsclc-therapy-sequencing-criteria/

Manem VS, Grassberger C, Paganetti H. Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers. 2017 Sep 6;9(9):119.

Grassberger C, Paganetti H. Varying relative biological effectiveness in proton therapy: knowledge gaps versus clinical significance. Acta oncologica (Stockholm, Sweden). 2017 Jun;56(6):761.

Grassberger C, Scott JG, Paganetti H. Biomathematical Optimization of Radiation Therapy in the Era of Targeted Agents. International Journal of Radiation Oncology• Biology• Physics. 2017 Jan 1;97(1):13-7.

Grassberger C, Paganetti H. Methodologies in the modeling of combined chemo-radiation treatments. Physics in medicine and biology. 2016 Oct 19;61(21):R344.

Verburg JM, Grassberger C, Dowdell S, Schuemann J, Seco J, Paganetti H. Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technology in cancer research & treatment. 2015;1533034615614139.

Varlotto J, DiMaio C, Grassberger C, Tangel M, Mackley H, Pavelic M, Specht C et al. Multi- modality management of craniopharyngioma: a review of various treatments and their outcomes. Neuro Oncology Practice. 2015;10.1093/nop/npv029.

Schuemann J, Giantsoudi D, Grassberger C, Moteabbed M, Min CH, Paganetti H. Assessing the clinical impact of approximations in analytical dose calculations for proton therapy. International Journal of Radiation Oncology* Biology* Physics. 2015;92(5):1157-64.

Dowdell S, Grassberger C, Sharp G, Paganetti H. Fractionated Lung IMPT Treatments Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technology in cancer research & treatment. 2015:1533034615595761.

Kooy HM, Grassberger C. Intensity modulated proton therapy. The British journal of radiology. 2015;88(1051):20150195.

Grassberger C, Dowdell S, Sharp G, Paganetti H. Motion mitigation for lung cancer patients treated with active scanning proton therapy. Medical physics. 2015;42(5):2462-9.

Grassberger C, Lomax A, Paganetti H. Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Physics in medicine and biology. 2014;60(2):633.

Phillips J, Gueorguiev G, Shackleford JA, Grassberger C, Dowdell S, Paganetti H, Sharp GC. Computing proton dose to irregularly moving targets. Physics in medicine and biology. 2014;59(15):4261.

Schuemann J, Dowdell S, Grassberger C, Min CH, Paganetti H. Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Physics in medicine and biology. 2014;59(15):4007.

Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H. Quantification of proton dose calculation accuracy in the lung. International Journal of Radiation Oncology* Biology* Physics. 2014;89(2):424-30.

Dowdell S, Grassberger C, Paganetti H. Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments. Medical physics. 2013;40(12):121713.

Giantsoudi D, Grassberger C, Craft D, Niemierko A, Trofimov A, Paganetti H. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. International Journal of Radiation Oncology* Biology* Physics. 2013;87(1):216-22.

Grassberger C, Dowdell S, Lomax A, et al. Motion Interplay as a Function of Patient Parameters and Spot Size in Spot Scanning Proton Therapy for Lung Cancer. International Journal of Radiation Oncology*Biology*Physics. 2013;86:380–386.

(featured in medicalphysicsweb:   http://medicalphysicsweb.org/cws/article/research/53114) 

Dowdell S, Grassberger C, Sharp GC, et al. Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Phys Med Biol. 2013;58:4137–4156.

Giantsoudi D, Grassberger C, Craft D, et al. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. Int J Radiat Oncol Biol Phys. 2013;87:216–222.

(featured in medicalphysicsweb:    http://medicalphysicsweb.org/cws/article/research/54274) 

Zeng C, Giantsoudi D, Grassberger C, et al. Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions. Med. Phys. 2013;40:051708.

Carabe A, España S, Grassberger C, et al. Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol. 2013;58:2103–2117.

Grassberger C, Paganetti H. Elevated LET components in clinical proton beams. Phys Med Biol. 2011;56:6677–6691.

Grassberger C, Trofimov A, Lomax A, et al. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011;80:1559–1566.

(featured in medicalphysicsweb:     http://medicalphysicsweb.org/cws/article/research/45093)  

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