Clemens Grassberger, PhD

Research Fellow
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 617 724 1202

Education and Degrees

BSc Physics ETH: Eidgenössische Technische Hochschule Zürich, Switzerland, 2008

Foreign Stipendiary: Ecole Normale Superieure Paris, France, 2009

MSc Physics ETH: Eidgenössische Technische Hochschule Zürich, Switzerland, 2010

PhD Physics: Eidgenössische Technische Hochschule Zürich, Switzerland, 2014


2016 ASTRO Young Investigator Award, Clinical Category

2013 AAPM Young Investigator Award, 2nd place

Areas of Interest

    Modeling the interaction of targeted agents and radiation
    Overcoming Resistant tumor sub-populations (CSCs)
    Biologically motivated treatment planning
    Modeling of radiation damage to DNA
    Early response assessment for tumor control and toxicity in NSCLC
    In-treatment imaging (FLT-PET, MRI)
    Lymphocyte cell populations as markers of treatment response
Monte Carlo
    Proton Therapy in the treatment of lung cancer
    Planning Strategies for treating mobile lung tumors with Active Scanning
    Monte Carlo methods to reduce calculation uncertainties


Grassberger C, Dowdell S, Lomax A, et al. Motion Interplay as a Function of Patient Parameters and Spot Size in Spot Scanning Proton Therapy for Lung Cancer. International Journal of Radiation Oncology*Biology*Physics. 2013;86:380–386.

(featured in medicalphysicsweb: 

Dowdell S, Grassberger C, Sharp GC, et al. Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Phys Med Biol. 2013;58:4137–4156.

Giantsoudi D, Grassberger C, Craft D, et al. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. Int J Radiat Oncol Biol Phys. 2013;87:216–222.

(featured in medicalphysicsweb: 

Zeng C, Giantsoudi D, Grassberger C, et al. Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions. Med. Phys. 2013;40:051708.

Carabe A, España S, Grassberger C, et al. Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol. 2013;58:2103–2117.

Grassberger C, Paganetti H. Elevated LET components in clinical proton beams. Phys Med Biol. 2011;56:6677–6691.

Grassberger C, Trofimov A, Lomax A, et al. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011;80:1559–1566.

(featured in medicalphysicsweb:  

Located in: Research