David "Bo" McClatchy, PhD

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Current Position

Resident, Harvard Medical Physics Residency Program

Clinical Research Fellow, Radiation-Drug Treatment Design Lab (Advisors: Grassberger & Paganetti)


Ph.D., Engineering Sciences, Thayer School of Engineering, Dartmouth College, Hanover, NH, 2018

A.B., Engineering Sciences, Dartmouth College, Hanover, NH, 2013

  • Awarded Departmental High-Honors

Grants and Awards

  • F31 Pre-Doctoral National Research Service Award, NIH/NCI, 2016-2018
  • John W. Strohbehn, PhD Memorial Prize, Thayer School of Engineering, 2018
  • Travel Grant Recipient, The Neukom Institute for Computational Science, 2014

  • Travel Fellowship, UC Irvine National Short Course in Computational Biophotonics, 2013
  • Kaminsky Family Fund Award Grant, Dartmouth College Office of Undergraduate Research, 2013
  • John C. Woodhouse Engineering Design Prize, Thayer School of Engineering, 2012

  • Page Worthington Scholarship Fund, Dartmouth Club of Maryland, 2010


  1. Stephen C. Kanick, Brian W. Pouge, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy III, Venkatramanan Krishnaswamy. ”Structured-Light Imaging Systems and Methods for Determining Sub-Diffuse Scattering Parameters”, Application Filed February 2016, Application #: US 15/013,623
  2. Venkatramanan Krishnaswamy, Brian W. Pouge, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy III. ”Apparatus and Methods for Structured Light Scatteroscopy”, Application Filed February 2015, Application #: PCT/US2015/014416
  3. Jay Vincelli, David McClatchy, Stephanie Wolf, Ryan Halter, James Yun, ”Miniaturized Cardiopulmonary Bypass Circuit for a Mouse Model”, Application Filed February 2014, Granted February 2017, US 9,561,315 B1


  1. Maloney, B.W., McClatchy, III, D. M., Pogue, B. W., Paulsen, K. D., W. A., and Barth, Jr., R.J., “Review of Methods for Intraoperative Margin Detection for Breast Conserving Surgery,” Journal of Biomedical Optics 23(10), 100901 (2018). DOI: 10.1117/1.JBO.23.10.100901
  2. McClatchy, III, D. M., Zuurbier, R. A., Wells, W. A., Paulsen, K. D., and Pogue, B. W., “Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro- CT readings to final histopathology,” Breast Cancer Research and Treatment, 1–9 (2018). DOI: 10.1007/s10549-018-4951-3
  3. McClatchy, III, D. M., Rizzo, E. J., Kanick, S. C., Wells, W. A., Black, C. C., Paulsen, K. D., and Pogue, B. W., “Light scattering measured with spatial frequency domain imaging can predict stromal versus epithelial proportions in surgically resected breast tissue,” Journal of Biomedical Optics 24(7), 071605 (2018). DOI: 10.1117/1.JBO.24.7.071605
  4. McClatchy, III, D. M., Rizzo, E. J., Meganck, J., Kemper, J., Vicory, J., Wells, W. A., Paulsen, K. D., and Pogue, B. W., “Calibration and analysis of a multimodal micro-CT and structured light imaging system for the evaluation of excised breast tissue,” Physics in Medicine and Biology 62(23), 8983 (2017). DOI: 10.1088/1361-6560/aa94b6
  5. Carlson, M. L., McClatchy, III, D. M., Gunn, J., Elliott, J. T., Paulsen, K. D., Kanick, S. C., and Pogue, B. W., “Wide-field color imaging of scatter-based tis- sue contrast using both high spatial frequency illumination and cross-polarization gating,” Journal of Biophotonics 10, 1864–0648 (2017). DOI: 10.1002/jbio.201700104
  6. McClatchy, D. M., Hoopes, P. J., Pogue, B. W., and Kanick, S. C., “Monochromatic subdiffusive spatial frequency domain imaging provides in-situ sensitivity to intratumoral morphological heterogeneity in a murine model,” Journal of Biophotonics 10(2), 211–216 (2017). Back Cover Issue DOI: 10.1002/jbio.201600181
  7. McClatchy, D. M., Rizzo, E. J., Wells, W. A., Cheney, P. P., Hwang, J. C., Paulsen, K. D., Pogue, B. W., and Kanick, S. C., “Wide-field quantitative imaging of tissue microstructure using sub-diffuse spatial frequency domain imaging,” Optica 3, 613–621 (Jun 2016). DOI: 10.1364/OPTICA.3.000613
  8. McClatchy, III, D. M., Krishnaswamy, V., Kanick, S. C., Elliott, J. T., Wells, W. A., Barth, Jr., R. J., Paulsen, K. D., and Pogue, B. W., “Molecular dyes used for surgical specimen margin orientation allow for intraoperative optical as- sessment during breast conserving surgery,” Journal of Biomedical Optics 20(4), 040504 (2015). DOI: 10.1117/1.JBO.20.4.040504
  9. Kanick, S. C., McClatchy, D. M., Krishnaswamy, V., Elliott, J. T., Paulsen, K. D., and Pogue, B. W., “Sub-diffusive scattering parameter maps recovered using wide-field high-frequency structured light imaging,” Biomedical Optics Express 5, 3376–3390 (Oct 2014). DOI: 10.1364/BOE.5.003376
  10. Krishnaswamy, V., Elliott, J. T., McClatchy, III, D. M., Barth, Jr., R. J., Wells, W. A., Pogue, B. W., and Paulsen, K. D., “Structured light scatteroscopy,” Journal of Biomedical Optics 19(7), 070504 (2014). DOI: 10.1117/1.JBO.19.7.070504
  11. Sexton, K., Davis, S. C., McClatchy, D., Valdes, P. A., Kanick, S. C., Paulsen, K. D., Roberts, D. W., and Pogue, B. W., “Pulsed-light imaging for fluorescence guided surgery under normal room lighting,” Optics Letters 38, 3249–3252 (Sep 2013). DOI: 10.1364/OL.38.003249
  12. Glaser, A. K., Davis, S. C., McClatchy, D. M., Zhang, R., Pogue, B. W., and Gladstone, D. J., “Projection imaging of photon beams by the Cˇerenkov effect,” Medical Physics 40(1), 012101 (2013). DOI: 10.1118/1.4770286