Hsiao-Ming Lu, PhD

Director of Clinical Physics
Associate Professor
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Address: Department of Radiation Oncology, Massachusetts General Hospital
55 Fruit Street, Boston, MA 02114
Phone: 617 726 6924

Education and Degrees

  • B.S., Nanjing University, China, 1982, Nuclear Physics
  • Ph.D., Arizona State University, U.S.A., 1988, Condensed Matter Physics


  • Therapeutic Radiologic Physics, American Board of Radiology, 1999-.

Areas of Research Interest

Proton therapy, proton radiography, in-vivo range verification, image-guided radiotherapy

Recent Publications

Ayan AS, Lin H, Yeager C, Deville C, McDonough J, Zhu TC, Anderson N, Bar Ad V, Lu HM, Both S. Should image rotation be addressed during routine cone-beam CT quality assurance? Physics in Medicine and Biology 2013; 58, 1059-73.

Macdonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, Smith BL, Yeap BY, Adams J, Delaney TF, Kooy H, Lu HM, Taghian AG. Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial. International Journal of Radiation Oncology, Biology, Physics. 2013 Jul 1; 86(3):484-90.

Macdonald SM, Jimenez R, Paetzold P, Adams J, Beatty J, Delaney TF, Kooy H, Taghian AG, Lu HM. Proton radiotherapy for chest wall and regional lymphatic radiation; dose comparisons and treatment delivery. Radiation Oncology 2013; 8:71.

Christodouleas JP, Tang S, Susil RC, McNutt TR, Song DY, Bekelman J, Deville C, Vapiwala N, Deweese TL, Lu HM, Both S. The effect of anterior proton beams in the setting of a prostate-rectum spacer. Medical Dosimetry 2013; 38(3):315-9.

Jimenez RB, Goma C, Nyamwanda J, Kooy HM, Halabi T, Napolitano BN, McBride SM, Taghian AG, Lu HM, Macdonald SM. Intensity modulated proton therapy for postmastectomy radiation of bilateral implant reconstructed breasts: A treatment planning study. Radiotheray and Oncology. 2013 May; 107(2):213-7

Wang Y, Efstathiou JA, Lu HM, Sharp GC, Trofimov A. Hypofractionated proton therapy for prostate cancer: Dose delivery uncertainty due to interfractional motion. Medical Physics 2013 Jul; 40(7):071714.

Testa M, Verburg JM, Rose M, Min CH, Tang S, Bentefour el H, Paganetti H, Lu HM. Proton radiography and proton computed tomography based on time-resolved dose measurements. Phys Med Biol. 2013 Nov 21; 58(22):8215-33.

Hong TS, DeLaney TF, Mamon HJ, Willet CG, Yeap BY, Niemierko A, Wolfgang JA, Lu HM, Adams J, Weyman EA, Arellano RS, Blaszkowsky LS, Allen JN, Tanabe KK, Ryan DP, Zhu AX. A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors. Practical Radiation Oncology. 2014 September; 4(5); 316-322.

Testa M, Schumann J, Lu HM, Shin J, Faddegon B, Perl J,Paganetti H. Experimental validation of teh TOPAS Mnote-Carlo system for passive scattering proton therapy. Medical Physics 2013 Dec; 40(12):121719.

Zhu MY, Botticello T, Lu HM, Winey B. Long-term stability and mechanical characteristics of kV digital imaging system for proton therapy. Medical Physics 2014 April; 41(1), 041706-1.

Gerweck LE, Huang P, Lu HM, Paganetti H, Zhou Y. Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons. International Journal of Radiation Oncology, Biology, Physics. 2014; 89(1):161-6.

Halabi T, Lu HM. Automating checks of plan check automation. J Appl Clin Med Phys 2014; 15(4):4889.

Testa M, Min CH, Verburg JM, Schumann J, Lu HM, Paganetti H. Range verification of passively scattered proton beams based on prompt gamma time patterns. Phys Med Biol. 2014 Jul 8; 59(15):4181-95.

Moteabbed M, Sharp GC, Wang Y, Trofimov A, Efstathiou JA, Lu HM. Validation of a deformable image registration technique for cone beam CT-based dose verification. Med Phys. 2015 Jan; 42(1):196.

Depauw N, Batin E, Daartz J, Rosenfeld A, Adams J, Kooy H, MacDonald S, Lu HM. A novel approach to postmastectomy radiation therapy using scanned proton beams. Int J Radiat Oncol Biol Phys. 2015 Feb 1; 91(2):427-34.

Doolan PJ, Testa M, Sharp GC, Bentefour EH, Royle G, Lu HM. Patient-specific stopping power calibration for proton therapy planning based on single-detector for proton radiography. Phys Med Biol 2015 60(5):1901-7.

Liu Q, Ghosh P, Magpayo N, Testa M, Tang, S, Gheorghiu L, Biggs P, Paganetti H, Efstathiou J, Lu HM, Held KD, Willers H. Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation. Int J Radiat Oncol Biol Phys. 2015; 91(5):1081-9.

Located in: Leadership