Jan Unkelbach, Ph.D.

    Assistant Professor of Radiation Oncology
    Massachusetts General Hospital and Harvard Medical School
    Department of Radiation Oncology
    Phone: (617) 643 6690
    Email: junkelbach (at) partners.org

Education and Degrees:

    Bachelor: University of Manchester Institute of Science and Technology (UMIST), UK, 2000, Physics
    MS (Diploma): Technical University Berlin, Germany, 2002, Physics
    Ph.D.: University of Heidelberg, Germany, 2006, Physics
Work experience:

   2002-2006 Researcher at the German Cancer Research Center (DKFZ) in Heidelberg, Germany

   2006-2008 Post-doctoral Fellow at Massachusetts General Hospital, Boston, MA

   2008-2009 Post-doctoral Fellow at Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA), Lugano, Switzerland

   2010-          Assistant Professor of Radiation Oncology, Massachusetts General Hospital, Boston, MA

Areas of Interest

    Treatment plan optimization for Intensity Modulated Photon/Proton Therapy

    Robust optimization for handling range and setup uncertainties in IMPT optimization

    Direct aperture optimization

    Rotation therapy treatment plan optimization

    Modeling glioblastoma growth for radiotherapy planning

    Optimal fractionation and spatio-temporal treatment planning


Spring 2011/2012/2014: "Physics of Proton Radiation Therapy" (HST 531) in the HST program by MIT/Harvard

Spring 2013/2015: "Optimization methods in radiation therapy and medical imaging" (HST 533) in the HST program by MIT/Harvard

Selected Publications

Unkelbach J, Menze B, Motamedi A, Dittmann F, Konukoglu E, Ayache N, and Shih H. Radiotherapy planning for glioblastoma based on a tumor growth model: improving target volume delineation. Phys. Med. Biol., 2014, 59(3):747-770

Unkelbach J, Zeng C, Engelsman M. Simultaneous optimization of dose distributions and fractionation schemes in particle radiotherapy. Med. Phys. 2013;40(9):091702

Unkelbach J, et al. Exploiting tumor shrinkage through temporal optimization of radiotherapy. Phys. Med. Biol. 2014;59:3059-3079

Unkelbach J, Craft D, Salari E, Ramakrishnan J, and Bortfeld T. The dependence of optimal fractionation schemes on the spatial dose distribution. Phys. Med. Biol. 2013;58(1):159-6Salari E and Unkelbach J. A column generation based technique for direct aperture optimization. Phys. Med. Biol. 2013;58:p621-39

Cassioli A and Unkelbach J. Aperture shape optimization for IMRT treatment planning. Phys. Med. Biol. 2013;58(2):301-18 

Chen W, Unkelbach J, Trofimov A, Madden T, Kooy H, Bortfeld T, and Craft D. Including robustness in multi-criteria optimization for intensity-modulated proton therapy. Phys. Med. Biol. 2012;57:591-608

Unkelbach J, Soukup M, Martin B, and Bortfeld T. Reducing the sensitivity of IMPT treatment plans to setup errors and range uncertainties via probabilistic treatment planning Med Phys 2009;36(1):149-163.

Unkelbach J, Chan TCY and Bortfeld T. Accounting for range uncertainties in the optimization of intensity modulated proton therapy. Phys Med Biol 2007;52:2755-73

Unkelbach J. Inclusion of organ motion in IMRT optimization using probabilistic treatment planning. PhD thesis 2006 http://www.ub.uni-heidelberg.de/archiv/6139/

Unkelbach J and Oelkfe U. Inclusion of organ movements in IMRT treatment planning via inverse planning based on probability distributions Phys Med Biol 2004;49:4005-29.