Instructor, Harvard Medical School
Massachusetts General Hospital
Department of Radiation Oncology

Phone: 617-726-9667
Email: jwolfgang(at)

Education and Degrees:

B.S.: University of Arizona, 1992, Physics
M.S.: Texas A&M University - Commerce, 1996, Physics
M.S.: Rice University, 2000, Applied Physics
Ph.D.: Rice University, 2000, Applied Physics

Areas of Interest:

Charged Particle Radiotherapy

GI Radiotherapy, SBRT

Visualization and Computation in Radiotherapy

Interoperability Issues in Radiotherapy

           Research Group Web Page


Risser SM, Wolfgang J, FerrisKF. N-State Interpretation of the First and Second Hyperpolarizabilities of Cyanobiphenyl-Based Liquid Crystal Molecules. Mol. Cryst. Liq. Cryst. 1996;309:133-42


Wolfgang J, Risser SM, Priyadarshy S, Beratan DN. Secondary Structure Conformations and Long Range Electronic Interactions in Oligopeptides. J. Phys. Chem. B. 1997;101(15):2986-91


Parthasarathy R, Finch CD, Wolfgang J, Nordlander P, Dunning FB. Low-energy dissociative electron attachment to CH­­2Br2, CHClBr2, and CCl3Br: Intermediate lifetimes and decay energetics. J. Chem. Phys. 1998;109:8829-35

Houssiau L, Rabalais W, Wolfgang J, Nordlander P. Surface structure and electron density dependence of Ne+ ion fractions from Cd- and S-terminated CdS{0001} surfaces. Phys. Rev. Lett. 1998;81:5153-6

Houssiau L, Rabalais W, Wolfgang J, Nordlander P. Trajectory Dependence of Scattered Ne+ and Recoiled S- Ion Fractions from the Cd- and S-Terminated CdS{0001} Surfaces. J. Chem. Phys. 1999;110:8139


Silva JAMC, Wolfgang J, Borisov AG, Gauyacq JP, Nordlander P, Teillet-Billy D.Resonant charge transfer process in ion-metal surface collisions: effect of the presence of vacancies on the surface. Nucl. Instrm. Meth B. 1999;157:55-60


Vaquilla I, Lui KM, Rabalais JW, Wolfgang J, Nordlander P. Surface structure and electron density dependence of scattered Ne+ ion fractions from the Si(100)-(2X1) surface. Surface Science 2001;255-264


Vaquilla I, Rabalais JW, Wolfgang J, Nordlander P. Doping dependence of electronic charge transfer on Si(100), Surf. Sci. Lett. 2001;L561-567


Westcott SL, Averitt RD, Wolfgang JA, Nordlander P, Halas NJ. Adsorbate-induced quenching of hot electrons in gold core-shell nanoparticles, J. Phys. Chem. 2001;B105:9913-9917


Silva JAMC, Wolfgang J, Borisov AG, Gauyacq JP, Nordlander P, Teillet-Billy D. Effect of a surface adatom on the resonant charge transfer between an H- ion and an Al surface, Surf. Sci. 2002;506:145-160


Wolfgang J. Medical Proton Accelerators. In: Boyer A, Kaylor S. editors. Web-based Dosimetry Training Program,, Stanford School of Medicine (Spring 2004)


Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R. Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy, Int J Radiat Oncol Biol Phys. 2005 Nov 15;63(4):1262-9


Neicu T, Berbeco R, Wolfgang J, Jiang S. Synchronized Moving Aperture Radiation Therapy (SMART): Improvement; of Breathing Pattern Reproducibility Using Respiratory Coaching, Phys. Med. Biol. 2006; 51(3):617-36


RietzelE, LiuAK, DoppkeKP, WolfgangJ, ChenAB, ChenGTY, Choi NC. Design of 4D treatment planning target volumes Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):287-95.


Flampouri, S., Jiang, S.B., Sharp, G.C., Wolfgang, J., Patel, A.A., Choi, N.C., Estimation of the delivered patient dose in lung IMRT treatment based on deformable registration of 4D-CT data and Monte Carlo simulations, Physics in Medicine and Biology 51 (11), art. no. 006, pp. 2763-2779


Dedual, N., Kaeli, D., Johnson, B., Chen, G., Wolfgang, J., Visualization of 4D computed tomography datasets, Proceedings of the IEEE Southwest Symposium on Image Analysis and Interpretation 2006, art. no. 1633734, pp. 120-123


Shinichiro Mori, Ph.D., John Wolfgang, Ph.D., Hsiao-Ming Lu, Ph.D., Robert Schneider, B.S., Noah C. Choi, M.D., And George T. Y. Chen, Ph.D. Quantitative Assessment Of Range Fluctuations In Charged Particle Lung Irradiation, Int J Radiat Oncol Biol Phys. (In Press)


Sher DJ, Wolfgang JA, Niemierko A, Choi NC. Quantification of mediastinal and hilar lymph node movement using four-dimensional computed tomography scan: implications for radiation treatment planning. Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1402-8. Epub 2007 Oct 24.


Shannon M MacDonald, Sairos Safai, Alexei Trofimov, John Wolfgang, Barbara Fullerton, , Beow Y Yeap, Thomas Bortfeld, Nancy J Tarbell, and Torunn Yock, Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons., Int J Radiat Oncol Biol Phys. 2008 Jul 15;71(4):979-86. Epub 2008 Mar 5.


Jiang SB, Wolfgang J, Mageras GS. Quality assurance challenges for motion-adaptive radiation therapy: gating, breath holding, and four-dimensional computed tomography. Int J Radiat Oncol Biol Phys. 2008;71(1 Suppl):S103-7.


MacDonald SM, Harisinghani MG, Katkar A, Napolitano B, Wolfgang J, Taghian AG. Nanoparticle-enhanced MRI to evaluate radiation delivery to the regional lymphatics for patients with breast cancer. MacDonald SM, Harisinghani MG, Katkar A, Napolitano B, Wolfgang J, Taghian AG


Patel AA, Wolfgang JA, Niemierko A, Hong TS, Yock T, Choi NC. Implications of respiratory motion as measured by four-dimensional computed tomography for radiation treatment planning of esophageal cancer. Int J Radiat Oncol Biol Phys. 2009 May 1;74(1):290-6.


Mori S, Lu HM, Wolfgang JA, Choi NC, Chen GT. Effects of interfractional anatomical changes on water-equivalent pathlength in charged-particle radiotherapy of lung cancer. J Radiat Res (Tokyo). 2009 Nov;50(6):513-9.


Sarker J, Chu A, Mui K, Wolfgang JA, Hirsch AE, Chen GT, Sharp GC. Variations in tumor size and position due to irregular breathing in 4D-CT: a simulation studyMed Phys. 2010 Mar;37(3):1254-60.


McGurk R, Seco J, Riboldi M, Wolfgang J, Segars P, Paganetti H. Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo. Phys Med Biol. 2010 Mar 7;55(5):1475-90. Epub 2010 Feb 16.


Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Kung JH, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, DeLaney TF. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. nt J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):843-50. Epub 2009 Dec 16.


Wolfgang J, Gemmel A, Lee J, Hasan M, Sharp G, Chen G. Development of a Volume Rendering Visualization Toolkit for Clinical Radiotherapy Applications. ICCR 2010 Conference Proceedings, 2010


Wo JY, Yoon SS, Guimaraes AR, Wolfgang J, Mamon HJ, Hong TS., Gastric lymph node contouring atlas: A tool to aid in clinical target volume definition in 3-dimensional treatment planning for gastric cancer. Pract Radiat Oncol. 2013 Jan-Mar;3(1):e11-9.


Unkelbach J, Craft D, Hong T, Papp D, Ramakrishnan J, Salari E, Wolfgang J, Bortfeld T., Exploiting tumor shrinkage through temporal optimization of radiotherapy.Phys Med Biol. 2014 Jun 21;59(12):3059-79


Hong T, DeLaney TF, Mamon H, Willett C, Yeap B, Niemierko A, Wolfgang J, Lu HM, Adams JA, Weyman E, Arellano R, Blaszkowsky L, Allen J, Tanabe K, Ryan D, Zhu A, A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors, Practical Radiation Oncology, In Press


Rochet N, Drake J, Harrington K, Wolfgang J, Napolitano B, Sadek B, Shenouda Keruakous A, Niemierko A, Taghain A, Deep Inspiration Breath-Hold Technique in Left Sided-Breast Cancer Radiotherapy: Evaluating Cardiac Contact Distance as a Predictor of Cardiac Exposure for Patient Selection, Practical Radiation Oncology, 2014, In Press